C Laird Birmingham1, Shelley Sidhu2, John Anderson3. 1. Department of Psychiatry, University of British Columbia, Suite 212, 2628 Granville Street, Vancouver, BC, V6H 4B4, Canada. carl.birmingham@ubc.ca. 2. Department of Psychiatry, University of British Columbia, Suite 212, 2628 Granville Street, Vancouver, BC, V6H 4B4, Canada. 3. Minnesota Neurotherapy Institute, Suite 221, 5871 Cedar Lake Rd S, Saint Louis Park, MN, 55416, USA.
Abstract
PURPOSE: To determine whether the fear response is the same in AN as in controls. METHOD: We recorded the EEG in 10 participants with a history of AN and in 10 controls during a fear stimulus. The response of the brain was recorded using EEG LORETA. The recording was analyzed for a marked increase in activity in the amygdala, uncus, insula, and anterior cingulate from 300 to 500 ms following the stimulus. RESULTS: The order or response of the amygdala, uncus, insula, and anterior cingulate was not significantly different in AN and controls. CONCLUSION: These results suggest that the brain's response to a fear stimulus is not significantly different in AN and controls. LEVEL OF EVIDENCE: Level 3, case-control study.
PURPOSE: To determine whether the fear response is the same in AN as in controls. METHOD: We recorded the EEG in 10 participants with a history of AN and in 10 controls during a fear stimulus. The response of the brain was recorded using EEG LORETA. The recording was analyzed for a marked increase in activity in the amygdala, uncus, insula, and anterior cingulate from 300 to 500 ms following the stimulus. RESULTS: The order or response of the amygdala, uncus, insula, and anterior cingulate was not significantly different in AN and controls. CONCLUSION: These results suggest that the brain's response to a fear stimulus is not significantly different in AN and controls. LEVEL OF EVIDENCE: Level 3, case-control study.
Authors: Alessio Maria Monteleone; Giovanni Castellini; Umberto Volpe; Valdo Ricca; Lorenzo Lelli; Palmiero Monteleone; Mario Maj Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2017-03-01 Impact factor: 5.067
Authors: Rudolf Uher; Michael J Brammer; Tara Murphy; Iain C Campbell; Virginia W Ng; Steven C R Williams; Janet Treasure Journal: Biol Psychiatry Date: 2003-11-01 Impact factor: 13.382