Mikkel Brabrand1,2,3, Daniel Pilsgaard Henriksen4. 1. Department of Emergency Medicine, Hospital of South West Jutland, Finsensgade 35, 6700, Esbjerg, Denmark. mikkel.brabrand@rsyd.dk. 2. Department of Emergency Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark. mikkel.brabrand@rsyd.dk. 3. Institute of Regional Health Research, University of Southern Denmark, Finsensgade 35, 6700, Esbjerg, Denmark. mikkel.brabrand@rsyd.dk. 4. Department of Clinical Chemistry and Pharmacology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark.
Abstract
IMPORTANCE: The CURB-65 score is widely implemented as a prediction tool for identifying patients with community-acquired pneumonia (cap) at increased risk of 30-day mortality. However, since most ingredients of CURB-65 are used as general prediction tools, it is likely that other prediction tools, e.g. the British National Early Warning Score (NEWS), could be as good as CURB-65 at predicting the fate of CAP patients. OBJECTIVE: To determine whether NEWS is better than CURB-65 at predicting 30-day mortality of CAP patients. DESIGN: This was a single-centre, 6-month observational study using patients' vital signs and demographic information registered upon admission, survival status extracted from the Danish Civil Registration System after discharge and blood test results extracted from a local database. SETTING: The study was conducted in the medical admission unit (MAU) at the Hospital of South West Jutland, a regional teaching hospital in Denmark. PARTICIPANTS: The participants consisted of 570 CAP patients, 291 female and 279 male, median age 74 (20-102) years. RESULTS: The CURB-65 score had a discriminatory power of 0.728 (0.667-0.789) and NEWS 0.710 (0.645-0.775), both with good calibration and no statistical significant difference. CONCLUSION: CURB-65 was not demonstrated to be significantly statistically better than NEWS at identifying CAP patients at risk of 30-day mortality.
IMPORTANCE: The CURB-65 score is widely implemented as a prediction tool for identifying patients with community-acquired pneumonia (cap) at increased risk of 30-day mortality. However, since most ingredients of CURB-65 are used as general prediction tools, it is likely that other prediction tools, e.g. the British National Early Warning Score (NEWS), could be as good as CURB-65 at predicting the fate of CAP patients. OBJECTIVE: To determine whether NEWS is better than CURB-65 at predicting 30-day mortality of CAP patients. DESIGN: This was a single-centre, 6-month observational study using patients' vital signs and demographic information registered upon admission, survival status extracted from the Danish Civil Registration System after discharge and blood test results extracted from a local database. SETTING: The study was conducted in the medical admission unit (MAU) at the Hospital of South West Jutland, a regional teaching hospital in Denmark. PARTICIPANTS: The participants consisted of 570 CAP patients, 291 female and 279 male, median age 74 (20-102) years. RESULTS: The CURB-65 score had a discriminatory power of 0.728 (0.667-0.789) and NEWS 0.710 (0.645-0.775), both with good calibration and no statistical significant difference. CONCLUSION: CURB-65 was not demonstrated to be significantly statistically better than NEWS at identifying CAP patients at risk of 30-day mortality.
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