Literature DB >> 29541366

Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus.

Shuaishuai Ni1, Baoli Li1, Feifei Chen2, Hanwen Wei1, Fei Mao1, Yifu Liu1, Yixiang Xu1, Xiaoxi Qiu1,1, Xiaokang Li1, Wenwen Liu1, Linghao Hu1, Dazheng Ling1, Manjiong Wang1, Xinyu Zheng1, Jin Zhu1, Lefu Lan2, Jian Li1.   

Abstract

Diapophytoene desaturase (CrtN) is a potential novel target for intervening in the biosynthesis of the virulence factor staphyloxanthin. In this study, 38 1,4-benzodioxan-derived CrtN inhibitors were designed and synthesized to overwhelm the defects of leading compound 4a. Derivative 47 displayed superior pigment inhibitory activity, better hERG inhibitory properties and water solubility, and significantly sensitized MRSA strains to immune clearance in vitro. Notably, 47 displayed excellent efficacy against pigmented S. aureus Newman, Mu50 (vancomycin-intermediate MRSA, VISA), and NRS271 (linezolid-resistant MRSA, LRSA) comparable to that of linezolid and vancomycin in vivo.

Entities:  

Year:  2018        PMID： 29541366      PMCID： PMC5846034          DOI： 10.1021/acsmedchemlett.7b00501

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  25 in total

Review 1.  Host-pathogen interactions: redefining the basic concepts of virulence and pathogenicity.

Authors:  A Casadevall; L A Pirofski
Journal:  Infect Immun       Date:  1999-08       Impact factor: 3.441

2.  Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia.

Authors:  K McColl; L Murray; E El-Omar; A Dickson; A El-Nujumi; A Wirz; A Kelman; C Penny; R Knill-Jones; T Hilditch
Journal:  N Engl J Med       Date:  1998-12-24       Impact factor: 91.245

Review 3.  Resistance-resistant antibiotics.

Authors:  Eric Oldfield; Xinxin Feng
Journal:  Trends Pharmacol Sci       Date:  2014-11-05       Impact factor: 14.819

4.  Antibiotic tolerance facilitates the evolution of resistance.

Authors:  Irit Levin-Reisman; Irine Ronin; Orit Gefen; Ilan Braniss; Noam Shoresh; Nathalie Q Balaban
Journal:  Science       Date:  2017-02-09       Impact factor: 47.728

5.  Linezolid-resistant staphylococcal bacteraemia: A multicentre case-case-control study in Italy.

Authors:  Alessandro Russo; Floriana Campanile; Marco Falcone; Carlo Tascini; Matteo Bassetti; Paola Goldoni; Maria Trancassini; Paola Della Siega; Francesco Menichetti; Stefania Stefani; Mario Venditti
Journal:  Int J Antimicrob Agents       Date:  2014-12-30       Impact factor: 5.283

6.  Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN).

Authors:  Youxin Wang; Hongxia Di; Feifei Chen; Yong Xu; Qiang Xiao; Xuehai Wang; Hanwen Wei; Yanli Lu; Lingling Zhang; Jin Zhu; Lefu Lan; Jian Li
Journal:  J Med Chem       Date:  2016-05-09       Impact factor: 7.446

7.  A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.

Authors:  Chia-I Liu; George Y Liu; Yongcheng Song; Fenglin Yin; Mary E Hensler; Wen-Yih Jeng; Victor Nizet; Andrew H-J Wang; Eric Oldfield
Journal:  Science       Date:  2008-02-14       Impact factor: 47.728

8.  Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.

Authors:  Yongcheng Song; Chia-I Liu; Fu-Yang Lin; Joo Hwan No; Mary Hensler; Yi-Liang Liu; Wen-Yih Jeng; Jennifer Low; George Y Liu; Victor Nizet; Andrew H-J Wang; Eric Oldfield
Journal:  J Med Chem       Date:  2009-07-09       Impact factor: 7.446

9.  Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus.

Authors:  B Wieland; C Feil; E Gloria-Maercker; G Thumm; M Lechner; J M Bravo; K Poralla; F Götz
Journal:  J Bacteriol       Date:  1994-12       Impact factor: 3.490

10.  Healthcare utilization and costs associated with S. aureus and P. aeruginosa pneumonia in the intensive care unit: a retrospective observational cohort study in a US claims database.

Authors:  Moe H Kyaw; David M Kern; Siting Zhou; Ozgur Tunceli; Hasan S Jafri; Judith Falloon
Journal:  BMC Health Serv Res       Date:  2015-06-21       Impact factor: 2.655
View more
  3 in total

1.  Biochanin A as an α-hemolysin inhibitor for combating methicillin-resistant Staphylococcus aureus infection.

Authors:  Jiaxuan Feng; Dazhong Sun; Li Wang; Xueting Li; Jiyu Guan; Lin Wei; Donghui Yue; Xingye Wang; Yicheng Zhao; Haimiao Yang; Wu Song; Bingmei Wang
Journal:  World J Microbiol Biotechnol       Date:  2021-11-27       Impact factor: 3.312

2.  Schinus terebinthifolia leaf lectin (SteLL) has anti-infective action and modulates the response of Staphylococcus aureus-infected macrophages.

Authors:  Isana Maria de Souza Feitosa Lima; Adrielle Zagmignan; Deivid Martins Santos; Hermerson Sousa Maia; Lucas Dos Santos Silva; Brenda da Silva Cutrim; Silvamara Leite Vieira; Clovis Macêdo Bezerra Filho; Eduardo Martins de Sousa; Thiago Henrique Napoleão; Karen Angeliki Krogfelt; Anders Løbner-Olesen; Patrícia Maria Guedes Paiva; Luís Cláudio Nascimento da Silva
Journal:  Sci Rep       Date:  2019-12-03       Impact factor: 4.379

Review 3.  Staphyloxanthin as a Potential Novel Target for Deciphering Promising Anti-Staphylococcus aureus Agents.

Authors:  Rana A Elmesseri; Sarra E Saleh; Heba M Elsherif; Ibrahim S Yahia; Khaled M Aboshanab
Journal:  Antibiotics (Basel)       Date:  2022-02-23
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.