Literature DB >> 29540776

Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium.

Shotaro Hoshino1, Chin Piow Wong1, Masahiro Ozeki1, Huiping Zhang2, Fumiaki Hayashi2, Takayoshi Awakawa1, Shumpei Asamizu3, Hiroyasu Onaka3, Ikuro Abe4.   

Abstract

New polycyclic tetramate macrolactams, Umezawamides A (1) and B (2) were isolated from a combined-culture of Umezawaea sp. RD066910 and mycolic-acid containing bacterium Tsukamurella pulmonis TP-B0596. Their planar structures and partial stereochemistries were determined based on the spectroscopic analysis, MMFF conformational search, and ECD calculations. Umezawamides are the first secondary metabolites isolated from the genus Umezawaea and they exhibited cytotoxicities to P388 murine leukemia cells. Furthermore, umezawamide A (1) showed growth inhibitory activity against Candida albicans.

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Year:  2018        PMID： 29540776     DOI： 10.1038/s41429-018-0040-4

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

Review 1.  A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters.

Authors:  Brett C Covington; Fei Xu; Mohammad R Seyedsayamdost
Journal:  Annu Rev Biochem       Date:  2021-04-13       Impact factor: 27.258

Review 2.  Discovery of novel secondary metabolites encoded in actinomycete genomes through coculture.

Authors:  Ji Hun Kim; Namil Lee; Soonkyu Hwang; Woori Kim; Yongjae Lee; Suhyung Cho; Bernhard O Palsson; Byung-Kwan Cho
Journal:  J Ind Microbiol Biotechnol       Date:  2021-06-04       Impact factor: 4.258

3.  Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams.

Authors:  Wei Liu; Wenjun Zhang; Hongbo Jin; Qingbo Zhang; Yuchan Chen; Xiaodong Jiang; Guangtao Zhang; Liping Zhang; Weimin Zhang; Zhigang She; Changsheng Zhang
Journal:  Mar Drugs       Date:  2019-11-25       Impact factor: 5.118

4.  High Culturable Bacterial Diversity From a European Desert: The Tabernas Desert.

Authors:  Esther Molina-Menor; Helena Gimeno-Valero; Javier Pascual; Juli Peretó; Manuel Porcar
Journal:  Front Microbiol       Date:  2021-01-08       Impact factor: 5.640

Review 5.  Extending the "One Strain Many Compounds" (OSMAC) Principle to Marine Microorganisms.

Authors:  Stefano Romano; Stephen A Jackson; Sloane Patry; Alan D W Dobson
Journal:  Mar Drugs       Date:  2018-07-23       Impact factor: 5.118
  5 in total

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