Literature DB >> 29540454

One Year in the Life of a Rapid Syndromic Panel for Meningitis/Encephalitis: a Pediatric Tertiary Care Facility's Experience.

Samia N Naccache1, Maryann Lustestica1, Margil Fahit1, Javier Mestas1, Jennifer Dien Bard2,3.   

Abstract

Early establishment of infectious processes allows for expedited clinical management of meningitis and encephalitis. The FilmArray meningitis/encephalitis (FA-M/E) panel provides rapid detection of potential pathogens associated with encephalitis/meningitis in both immunocompetent and compromised patients. Here, we conducted a 1-year review of the performance of the FA-M/E panel at a tertiary care children's hospital. Two hundred sixty-five samples from 251 patients were tested. We found 87.25% (219/251) were negative, 9.96% (25/251) were positive for viral analytes, and 3.19% (8/251) were positive for bacterial analytes. When possible, positive results were confirmed by alternate testing; 4/6 available bacterial positives and 17/20 available viral positives were confirmed by retrospective culture or molecular testing.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  FilmArray; encephalitis; meningitis; pediatric; syndromic panel

Mesh：

Substances：

Year:  2018        PMID： 29540454      PMCID： PMC5925728          DOI： 10.1128/JCM.01940-17

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  25 in total

1.  Multiplex PCR and a chromogenic DNA macroarray for the detection of Listeria monocytogens, Staphylococcus aureus, Streptococcus agalactiae, Enterobacter sakazakii, Escherichia coli O157:H7, Vibrio parahaemolyticus, Salmonella spp. and Pseudomonas fluorescens in milk and meat samples.

Authors:  Yu-Cheng Chiang; Hau-Yang Tsen; Hsin-Yen Chen; Yu-Hsin Chang; Chien-Ku Lin; Chih-Yuan Chen; Wan-Yu Pai
Journal:  J Microbiol Methods       Date:  2011-11-12       Impact factor: 2.363

2.  Utility of FilmArray Meningitis/Encephalitis Panel during Outbreak of Brainstem Encephalitis Caused by Enterovirus in Catalonia in 2016.

Authors:  Cristian Launes; Didac Casas-Alba; Claudia Fortuny; Ana Valero-Rello; Maria Cabrerizo; Carmen Muñoz-Almagro
Journal:  J Clin Microbiol       Date:  2016-12-28       Impact factor: 5.948

3.  Lumbar puncture in pediatric bacterial meningitis: defining the time interval for recovery of cerebrospinal fluid pathogens after parenteral antibiotic pretreatment.

Authors:  J T Kanegaye; P Soliemanzadeh; J S Bradley
Journal:  Pediatrics       Date:  2001-11       Impact factor: 7.124

4.  Comparative evaluation of the FilmArray meningitis/encephalitis molecular panel in a pediatric population.

Authors:  Erin H Graf; Maria Victoria Farquharson; Ana María Cárdenas
Journal:  Diagn Microbiol Infect Dis       Date:  2016-10-01       Impact factor: 2.803

5.  Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters?

Authors:  Harmony P Garges; M Anthony Moody; C Michael Cotten; P Brian Smith; Kenneth F Tiffany; Robert Lenfestey; Jennifer S Li; Vance G Fowler; Daniel K Benjamin
Journal:  Pediatrics       Date:  2006-04       Impact factor: 7.124

6.  Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens.

Authors:  Amy L Leber; Kathy Everhart; Joan-Miquel Balada-Llasat; Jillian Cullison; Judy Daly; Sarah Holt; Paul Lephart; Hossein Salimnia; Paul C Schreckenberger; Sharon DesJarlais; Sharon L Reed; Kimberle C Chapin; Lindsay LeBlanc; J Kristie Johnson; Nicole L Soliven; Karen C Carroll; Jo-Anne Miller; Jennifer Dien Bard; Javier Mestas; Matthew Bankowski; Tori Enomoto; Andrew C Hemmert; Kevin M Bourzac
Journal:  J Clin Microbiol       Date:  2016-06-22       Impact factor: 5.948

7.  Evaluation and improvement of real-time PCR assays targeting lytA, ply, and psaA genes for detection of pneumococcal DNA.

Authors:  Maria da Gloria S Carvalho; Maria Lucia Tondella; Karen McCaustland; Luciana Weidlich; Lesley McGee; Leonard W Mayer; Arnold Steigerwalt; Melissa Whaley; Richard R Facklam; Barry Fields; George Carlone; Edwin W Ades; Ron Dagan; Jacquelyn S Sampson
Journal:  J Clin Microbiol       Date:  2007-05-30       Impact factor: 5.948

8.  Enhancing pathogen identification in patients with meningitis and a negative Gram stain using the BioFire FilmArray(®) Meningitis/Encephalitis panel.

Authors:  Susan H Wootton; Elizabeth Aguilera; Lucrecia Salazar; Andrew C Hemmert; Rodrigo Hasbun
Journal:  Ann Clin Microbiol Antimicrob       Date:  2016-04-21       Impact factor: 3.944

9.  Pitfalls Associated With the Use of Molecular Diagnostic Panels in the Diagnosis of Cryptococcal Meningitis.

Authors:  Jane A O'Halloran; Alexander Franklin; William Lainhart; Carey-Ann Burnham; William Powderly; Erik Dubberke
Journal:  Open Forum Infect Dis       Date:  2017-11-03       Impact factor: 3.835

10.  Delayed Diagnosis of Tuberculous Meningitis Misdiagnosed as Herpes Simplex Virus-1 Encephalitis With the FilmArray Syndromic Polymerase Chain Reaction Panel.

Authors:  Carlos A Gomez; Benjamin A Pinsky; Anne Liu; Niaz Banaei
Journal:  Open Forum Infect Dis       Date:  2016-12-07       Impact factor: 3.835
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  15 in total

1.  Utilization, Yield, and Accuracy of the FilmArray Meningitis/Encephalitis Panel with Diagnostic Stewardship and Testing Algorithm.

Authors:  M Jana Broadhurst; Shefali Dujari; Indre Budvytiene; Benjamin A Pinsky; Carl A Gold; Niaz Banaei
Journal:  J Clin Microbiol       Date:  2020-08-24       Impact factor: 5.948

2.  Pathogen or Bystander: Clinical Significance of Detecting Human Herpesvirus 6 in Pediatric Cerebrospinal Fluid.

Authors:  Utsav Pandey; Alexander L Greninger; Greg R Levin; Keith R Jerome; Vikram C Anand; Jennifer Dien Bard
Journal:  J Clin Microbiol       Date:  2020-04-23       Impact factor: 5.948

3.  Cerebrospinal Fluid Findings Are Poor Predictors of Appropriate FilmArray Meningitis/Encephalitis Panel Utilization in Pediatric Patients.

Authors:  Mimi R Precit; Rebecca Yee; Utsav Pandey; Margil Fahit; Cheryl Pool; Samia N Naccache; Jennifer Dien Bard
Journal:  J Clin Microbiol       Date:  2020-02-24       Impact factor: 5.948

4.  Human Herpesvirus-6 Detection in Cerebrospinal Fluid on the BioFire FilmArray Meningitis/Encephalitis Panel in a High Human Immunodeficiency Virus-Prevalence African Setting.

Authors:  James Milburn; Kwana Lechiile; Keatlaretse Siamisang; Christopher G Williams; Leah Owen; Ezekiel Gwakuba; Tichaona Machiya; Tshepo Leeme; Hannah E Barton; Ronan Doyle; Mark W Tenforde; Madisa Mine; David M Goldfarb; Margaret Mokomane; Joseph N Jarvis
Journal:  Open Forum Infect Dis       Date:  2022-05-17       Impact factor: 4.423

Review 5.  Group B Streptococcal Neonatal Meningitis.

Authors:  Teresa Tavares; Liliana Pinho; Elva Bonifácio Andrade
Journal:  Clin Microbiol Rev       Date:  2022-02-16       Impact factor: 50.129

6.  Clinical benefits of introducing real-time multiplex PCR for cerebrospinal fluid as routine diagnostic at a tertiary care pediatric center.

Authors:  Anna Eichinger; Alexandra Hagen; Melanie Meyer-Bühn; Johannes Huebner
Journal:  Infection       Date:  2018-09-05       Impact factor: 3.553

7.  A review of a 13-month period of FilmArray Meningitis/Encephalitis panel implementation as a first-line diagnosis tool at a university hospital.

Authors:  Agathe Boudet; Alix Pantel; Marie-Josée Carles; Hélène Boclé; Sylvie Charachon; Cécilia Enault; Robin Stéphan; Lucile Cadot; Jean-Philippe Lavigne; Hélène Marchandin
Journal:  PLoS One       Date:  2019-10-24       Impact factor: 3.240

8.  Virulence factors and antibiotic resistance properties of Streptococcus species isolated from hospital cockroaches.

Authors:  Mohammad Chehelgerdi; Reza Ranjbar
Journal:  3 Biotech       Date:  2021-06-10       Impact factor: 2.893

9.  FilmArray® meningitis/encephalitis (ME) panel, a rapid molecular platform for diagnosis of CNS infections in a tertiary care hospital in North India: one-and-half-year review.

Authors:  Bansidhar Tarai; Poonam Das
Journal:  Neurol Sci       Date:  2018-09-25       Impact factor: 3.830

10.  Implementation of the FilmArray ME panel in laboratory routine using a simple sample selection strategy for diagnosis of meningitis and encephalitis.

Authors:  Susanne Pfefferle; Martin Christner; Martin Aepfelbacher; Marc Lütgehetmann; Holger Rohde
Journal:  BMC Infect Dis       Date:  2020-02-22       Impact factor: 3.090
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