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Literature DB >> 2954027

Influence of renal and hepatic function on pharmacodynamics and pharmacokinetics of non-depolarizing muscle relaxants.

Abstract

Liver and kidney function disturbances influence the pharmacodynamic and pharmacokinetic behaviour of drugs. Because of the differences in metabolism and excretion between the various muscle relaxants, liver and kidney disturbances do influence their pharmacodynamics and pharmacokinetics to a different extent. A description of the changes is given for the most frequently used non-depolarizing muscle relaxants. It is related to the practical clinical implications of the difference in the pharmacokinetics.

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Year: 1987 PMID： 2954027 DOI： 10.1007/bf01960736

Source DB: PubMed Journal: Pharm Weekbl Sci ISSN： 0167-6555

37 in total

1. Pharmacokinetics of pancuronium in patients with normal and impaired renal function.

Authors: K McLeod; M J Watson; M D Rawlins
Journal: Br J Anaesth Date: 1976-04 Impact factor: 9.166

2. Prolonged intercostal paralysis due to a relaxant.

Authors: H B FAIRLEY
Journal: Br Med J Date: 1950-10-28

3. The effect of renal failure and hyperkalemia on the duration of pancuronium neuromuscular blockade in man.

Authors: R D Miller; W C Stevens; W L Way
Journal: Anesth Analg Date: 1973 Jul-Aug Impact factor: 5.108

4. The relationship between disposition and duration of action of congeneric series of steroidal neuromuscular blocking agents.

Authors: S Agoston; E J Crul; U W Kersten; M C Houwertjes; A H Scaf
Journal: Acta Anaesthesiol Scand Date: 1977 Impact factor: 2.105

Review 1. Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations.

Authors: D K Meijer; W E Mol; M Müller; G Kurz
Journal: J Pharmacokinet Biopharm Date: 1990-02

Review 2. Neuromuscular transmission and its pharmacological blockade. Part 4: Use of relaxants in paediatric and elderly patients, in obstetrics, and in the intensive care unit.

Authors: L H Booij
Journal: Pharm World Sci Date: 1997-02

2 in total

Influence of renal and hepatic function on pharmacodynamics and pharmacokinetics of non-depolarizing muscle relaxants.

1. Pharmacokinetics of pancuronium in patients with normal and impaired renal function.

2. Prolonged intercostal paralysis due to a relaxant.

3. The effect of renal failure and hyperkalemia on the duration of pancuronium neuromuscular blockade in man.

4. The relationship between disposition and duration of action of congeneric series of steroidal neuromuscular blocking agents.

5. Pharmacokinetics of pancuronium in patients with normal and impaired renal function.

6. Hepatic and renal disposition of pancuronium and gallamine in patients with extrahepatic cholestasis.

7. Althesin and pancuronium in chronic liver disease.

8. Bile salts and neuromuscular blocking agents.

9. Pharmacokinetics and pharmacodynamics of gallamine triethiodide in patients with total biliary obstruction.

10. The pharmacokinetics of d-tubocurarine in man with and without renal failure.

Review 1. Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations.

Review 2. Neuromuscular transmission and its pharmacological blockade. Part 4: Use of relaxants in paediatric and elderly patients, in obstetrics, and in the intensive care unit.