Literature DB >> 29540202

Correction to: The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma.

C Festuccia1, A Mancini2, A Colapietro2, G L Gravina2,3, F Vitale4, F Marampon3, S Delle Monache5, S Pompili6, L Cristiano7, A Vetuschi6, V Tombolini8, Y Chen9, T Mehrling10.   

Abstract

The original article [1] contained an error whereby Fig. 4 displayed incorrect magnification scales.

Entities:  

Year:  2018        PMID: 29540202      PMCID: PMC5853051          DOI: 10.1186/s13045-018-0587-3

Source DB:  PubMed          Journal:  J Hematol Oncol        ISSN: 1756-8722            Impact factor:   17.388


Erratum

The original article [1] contained an error whereby Fig. 4 displayed incorrect magnification scales.
Fig. 4

Morphological and functional effects of TINO when combined with RT in glioma cell lines. a Morphological changes observed in U251 cells after treatments with 2, 4, and 6 Gy (RT) alone or in association with TINO 3.5 μM. b Morphological changes observed in U87MG cells after treatments with 2, 4, and 6 Gy (RT) alone or in association with TINO 3.5 μM. c Representative expression of acidic vacuolar organelle (AVO) accumulation in T98G cells cultured with 2, 4, and 6 Gy (RT) alone or in association with TINO 3.5 μM. d Percentage of AVO-stained cells in U87MG, U251, and T98G cells cultured with 2, 4, and 6 Gy (RT) alone or in association with TINO 3.5 μM. Statistical analysis: *p < 0.005 in the comparison between combined TINO + RT treatment and RT alone. Single results are representative of three different experiments performed in triplicate. e Immunocytochemical evaluation of γH2Ax stain in T98G cells cultured with 4, 6, and 8 Gy (RT) alone or in association with TINO 3.5 μM. f Quantization of γH2AX expression in U87MG, U251, and T98G cells treated with RT with or without TINO. Statistical analyses: *p < 0.005 in the comparison between RT + TINO and RT or TINO treatments alone. Single results are representative of three different experiments performed in triplicate

Morphological and functional effects of TINO when combined with RT in glioma cell lines. a Morphological changes observed in U251 cells after treatments with 2, 4, and 6 Gy (RT) alone or in association with TINO 3.5 μM. b Morphological changes observed in U87MG cells after treatments with 2, 4, and 6 Gy (RT) alone or in association with TINO 3.5 μM. c Representative expression of acidic vacuolar organelle (AVO) accumulation in T98G cells cultured with 2, 4, and 6 Gy (RT) alone or in association with TINO 3.5 μM. d Percentage of AVO-stained cells in U87MG, U251, and T98G cells cultured with 2, 4, and 6 Gy (RT) alone or in association with TINO 3.5 μM. Statistical analysis: *p < 0.005 in the comparison between combined TINO + RT treatment and RT alone. Single results are representative of three different experiments performed in triplicate. e Immunocytochemical evaluation of γH2Ax stain in T98G cells cultured with 4, 6, and 8 Gy (RT) alone or in association with TINO 3.5 μM. f Quantization of γH2AX expression in U87MG, U251, and T98G cells treated with RT with or without TINO. Statistical analyses: *p < 0.005 in the comparison between RT + TINO and RT or TINO treatments alone. Single results are representative of three different experiments performed in triplicate This has now been corrected, and can be seen ahead and in the original article [1].
  1 in total

1.  The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma.

Authors:  Claudio Festuccia; Andrea Mancini; Alessandro Colapietro; Giovanni Luca Gravina; Flora Vitale; Francesco Marampon; Simona Delle Monache; Simona Pompili; Loredana Cristiano; Antonella Vetuschi; Vincenzo Tombolini; Yi Chen; Thomas Mehrling
Journal:  J Hematol Oncol       Date:  2018-02-27       Impact factor: 17.388

  1 in total
  2 in total

1.  Establishment and Characterization of a Reliable Xenograft Model of Hodgkin Lymphoma Suitable for the Study of Tumor Origin and the Design of New Therapies.

Authors:  Radhia M'kacher; Monika Frenzel; Mustafa Al Jawhari; Steffen Junker; Corina Cuceu; Luc Morat; Anne-Laure Bauchet; Lev Stimmer; Aude Lenain; Nathalie Dechamps; William M Hempel; Geraldine Pottier; Leonhard Heidingsfelder; Eric Laplagne; Claire Borie; Noufissa Oudrhiri; Dima Jouni; Annelise Bennaceur-Griscelli; Bruno Colicchio; Alain Dieterlen; Theodore Girinsky; Raphael Boisgard; Jean Bourhis; Jacques Bosq; Thomas Mehrling; Eric Jeandidier; Patrice Carde
Journal:  Cancers (Basel)       Date:  2018-10-31       Impact factor: 6.639

2.  Hydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual-Targeting HDAC Inhibitors and HDAC Degraders (PROTACs).

Authors:  Laura Sinatra; Jan J Bandolik; Martin Roatsch; Melf Sönnichsen; Clara T Schoeder; Alexandra Hamacher; Andrea Schöler; Arndt Borkhardt; Jens Meiler; Sanil Bhatia; Matthias U Kassack; Finn K Hansen
Journal:  Angew Chem Int Ed Engl       Date:  2020-10-09       Impact factor: 15.336

  2 in total

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