| Literature DB >> 29538735 |
Andoni Ramirez-Garcia1, Aize Pellon1, Aitor Rementeria1, Idoia Buldain1, Eliana Barreto-Bergter2, Rodrigo Rollin-Pinheiro2, Jardel Vieira de Meirelles2, Mariana Ingrid D S Xisto2, Stephane Ranque3, Vladimir Havlicek4, Patrick Vandeputte5,6, Yohann Le Govic5,6, Jean-Philippe Bouchara5,6, Sandrine Giraud6, Sharon Chen7, Johannes Rainer8, Ana Alastruey-Izquierdo9, Maria Teresa Martin-Gomez10, Leyre M López-Soria11, Javier Peman12, Carsten Schwarz13, Anne Bernhardt14, Kathrin Tintelnot14, Javier Capilla15, Adela Martin-Vicente15,16, Jose Cano-Lira15, Markus Nagl17, Michaela Lackner17, Laszlo Irinyi18, Wieland Meyer18, Sybren de Hoog19, Fernando L Hernando1.
Abstract
Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.Entities:
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Year: 2018 PMID： 29538735 DOI： 10.1093/mmy/myx113
Source DB: PubMed Journal: Med Mycol ISSN： 1369-3786 Impact factor: 4.076