| Literature DB >> 2953863 |
G Sperk, G P Reynolds, P Riederer.
Abstract
Size exclusion high performance liquid chromatography of post mortem human putamen samples revealed three somatostatin-immunoreactive peaks. The two major peaks cochromatographed with synthetic somatostatin-14 and somatostatin-28, respectively whereas the presumed somatostatin precursor preceded these peaks. In 11 samples obtained post mortem from patients suffering from Huntington's Disease somatostatin-like immunoreactivity was increased by about 55% in the mean. This increase was mainly due to increases in somatostatin-14 and--to a minor extent--of somatostatin-28, whereas the presumed precursor was not significantly changed.Entities:
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Year: 1987 PMID： 2953863 DOI： 10.1007/bf01244106
Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575