| Literature DB >> 29535142 |
Luis V Syro1, Fabio Rotondo2, Leon D Ortiz3, Kalman Kovacs2.
Abstract
Temozolomide is an alkylating chemotherapeutic agent used in malignant neuroendocrine neoplasia, melanoma, brain metastases and an essential component of adjuvant therapy in the treatment of glioblastoma multiforme and anaplastic astrocytoma. Since 2006, it has been used for the treatment of pituitary carcinomas and aggressive pituitary adenomas. Here, we discuss the current indications and results of temozolomide therapy in pituitary tumors, as well as frequently asked questions regarding temozolomide treatment, duration of therapy, dosage, tumor recurrence and resistance.Entities:
Keywords: chemotherapy; neoplasms; neuroendocrine tumors; pituitary; temozolomide
Mesh:
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Year: 2018 PMID: 29535142 DOI: 10.1530/ERC-18-0015
Source DB: PubMed Journal: Endocr Relat Cancer ISSN: 1351-0088 Impact factor: 5.678