Athanasios Tyraskis1, Spyros Bakalis2, Carolina Scala3, Argyro Syngelaki4, Stefano Giuliani5, Mark Davenport1, Anna L David2, Kypros Nicolaides4, Simon Eaton6, Paolo De Coppi7. 1. Paediatric Surgery Unit, King's College Hospital, London, UK. 2. Institute for Women's Health, University College London, UK. 3. Fetal Medicine Unit, St. George's Hospital, London, UK. 4. Harris Birthright Centre, King's College Hospital, London, UK. 5. Department of Paediatric and Neonatal Surgery, St. George's University Hospitals NHS Foundation Trust, Blackshaw Rd, SW17 0QT, London, UK. 6. Stem Cells and Regenerative Medicine, DBC, UCL Institute of Child Health and Great Ormond Street Hospital London, UK. 7. Stem Cells and Regenerative Medicine, DBC, UCL Institute of Child Health and Great Ormond Street Hospital London, UK. Electronic address: p.decoppi@ucl.ac.uk.
Abstract
AIM: We investigated the natural history of fetal ovarian cysts to estimate the risk of torsion according to size. METHODS: Cases were identified from 1/1/2000 until 1/1/2015. Data were collected pre- and postnatally on cyst size and sonographic features until an outcome of surgery, torsion, or resolution. Fisher's exact test for categorical data and logistic regression for continuous data were used to test the significance of size on torsion; P value <0.05 was considered significant. RESULTS: 37 patients with unilateral ovarian cysts were included. 12 (32%) resolved spontaneously prenatally, 14 (38%) resolved spontaneously postnatally, 5 (14%) underwent surgery postnatally and 6 (16%) cases underwent torsion. Rate of torsion increased with size from 0% (n=0) in cysts ≤20mm to 33% (n=2) in cysts >50mm; however, the overall trend failed to reach statistical significance (P=0.1). Cysts of 0-40mm had a significantly higher rate of spontaneous resolution (90% vs. 44% in >40mm, P=0.003), but the rate of torsion was not significantly different (10% in 0-40mm vs. 25% in >40mm, P=0.26). The median time to postnatal resolution was 10 (5-27) weeks in those treated conservatively. CONCLUSION: Cysts >40mm are significantly less likely to resolve spontaneously; however torsion showed no significant correlation with cyst size. No complications were observed in cysts <20mm. LEVEL OF EVIDENCE: IV, case series with no comparison group.
AIM: We investigated the natural history of fetal ovarian cysts to estimate the risk of torsion according to size. METHODS: Cases were identified from 1/1/2000 until 1/1/2015. Data were collected pre- and postnatally on cyst size and sonographic features until an outcome of surgery, torsion, or resolution. Fisher's exact test for categorical data and logistic regression for continuous data were used to test the significance of size on torsion; P value <0.05 was considered significant. RESULTS: 37 patients with unilateral ovarian cysts were included. 12 (32%) resolved spontaneously prenatally, 14 (38%) resolved spontaneously postnatally, 5 (14%) underwent surgery postnatally and 6 (16%) cases underwent torsion. Rate of torsion increased with size from 0% (n=0) in cysts ≤20mm to 33% (n=2) in cysts >50mm; however, the overall trend failed to reach statistical significance (P=0.1). Cysts of 0-40mm had a significantly higher rate of spontaneous resolution (90% vs. 44% in >40mm, P=0.003), but the rate of torsion was not significantly different (10% in 0-40mm vs. 25% in >40mm, P=0.26). The median time to postnatal resolution was 10 (5-27) weeks in those treated conservatively. CONCLUSION: Cysts >40mm are significantly less likely to resolve spontaneously; however torsion showed no significant correlation with cyst size. No complications were observed in cysts <20mm. LEVEL OF EVIDENCE: IV, case series with no comparison group.