Literature DB >> 29533611

Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca.

Rohitesh Kumar1, Sandra Duffy1, Vicky M Avery1, Anthony R Carroll1, Rohan A Davis1.   

Abstract

Chemical investigation of the roots of the Australian desert plant Eremophila microtheca yielded microthecaline A (1), a novel quinoline-serrulatane natural product. The structure of 1 was determined by spectroscopic analysis, and the absolute configuration was assigned by ECD. Compound 1 exhibited moderate antimalarial activity against Plasmodium falciparum (3D7 strain), with an IC50 of 7.7 μM. Microthecaline A represents the first quinoline-serrulatane alkaloid to be isolated from Nature.

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Year:  2018        PMID： 29533611     DOI： 10.1021/acs.jnatprod.7b00992

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

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Review 4.  Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies.

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  7 in total

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