| Literature DB >> 29532165 |
Laurens J De Sadeleer1,2, Ellen De Langhe3,4, Nicolas Bodart5, Alain Vigneron5, Xavier Bossuyt6,7, Wim A Wuyts8,9.
Abstract
Although included in the serological domain of the 'interstitial pneumonia with auto-immune features' (IPAF) research statement, the search for myositis-specific antibodies (MSA) is not incorporated in routine clinical practice. The objective of the study was to evaluate MSA prevalence in an idiopathic interstitial pneumonia (IIP) cohort (n = 68) with suggestive morphological interstitial lung disease patterns. Twelve of 68 patients (17.6%) carried MSA, whereof only two were anti-nuclear antibody-positive. Besides female gender, no demographic or pulmonary function parameter was predictive for MSA positivity. MSA were present in 32.4% of IPAF patients (n = 37), being essential for IPAF diagnosis in four of them (10.8%).Entities:
Keywords: Connective tissue disease-related lung disease; Interstitial lung diseases; Interstitial pneumonia with auto-immune features; Myositis-specific antibodies
Mesh:
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Year: 2018 PMID: 29532165 DOI: 10.1007/s00408-018-0108-8
Source DB: PubMed Journal: Lung ISSN: 0341-2040 Impact factor: 2.584