Racheal A Devine1, Zachary Diltz2, Mark W Hall1,2,3, Rajan K Thakkar1,2,4. 1. Center for Clinical and Translation Research, The Research Institute at Nationwide Children's Hospital700 Children's Drive, Columbus 43205, OH. 2. The Ohio State University College of Medicine370 W 9th Ave, Columbus 43210, OH. 3. Division of Critical Care Medicine, Nationwide Children's Hospital700 Children's Drive, Columbus 43205, OH. 4. Department of Pediatric Surgery, Nationwide Children's Burn Center, Nationwide Children's Hospital700 Children's Drive, Columbus 43205, OH.
Abstract
BACKGROUND: The immune response to critical injury, including thermal injury, can heavily influence the recovery and long term prognosis for patients suffering such insults. A growing body of evidence supports that a suppressed immunologic state following critical injury can lead to adverse outcomes for adult and pediatric patients. METHODS: A Pubmed literature search was conducted to review areas of the immune system that are impaired after thermal injury and identify key immune players that are potential targets for therapeutic intervention. The focus was pediatric thermal injury; however, where pediatric studies were lacking adult studies were used as reference. RESULTS: Changes in cytokine profiles and immune cell phenotypes have been observed following thermal injury. Treatment with immunomodulatory stimulants, including IL-7 and GM-CSF, lead to improved outcomes in critically ill patients and may also be useful tools to improve immune function in pediatric burn patients. CONCLUSIONS: The innate and adaptive branches of the systemic immune system are impaired following thermal injury in adult and pediatric patients. Immunomodulatory therapies currently being used in areas outside of thermal injury may be useful tools to help improve outcomes following pediatric thermal injury.
BACKGROUND: The immune response to critical injury, including thermal injury, can heavily influence the recovery and long term prognosis for patients suffering such insults. A growing body of evidence supports that a suppressed immunologic state following critical injury can lead to adverse outcomes for adult and pediatric patients. METHODS: A Pubmed literature search was conducted to review areas of the immune system that are impaired after thermal injury and identify key immune players that are potential targets for therapeutic intervention. The focus was pediatric thermal injury; however, where pediatric studies were lacking adult studies were used as reference. RESULTS: Changes in cytokine profiles and immune cell phenotypes have been observed following thermal injury. Treatment with immunomodulatory stimulants, including IL-7 and GM-CSF, lead to improved outcomes in critically illpatients and may also be useful tools to improve immune function in pediatric burn patients. CONCLUSIONS: The innate and adaptive branches of the systemic immune system are impaired following thermal injury in adult and pediatric patients. Immunomodulatory therapies currently being used in areas outside of thermal injury may be useful tools to help improve outcomes following pediatric thermal injury.
Authors: Tim Lögters; Stefan Margraf; Jens Altrichter; Jindrich Cinatl; Steffen Mitzner; Joachim Windolf; Martin Scholz Journal: Med Microbiol Immunol Date: 2009-08-04 Impact factor: 3.402
Authors: Peter Hampson; Robert J Dinsdale; Christopher M Wearn; Amy L Bamford; Jonathan R B Bishop; Jon Hazeldine; Naiem S Moiemen; Paul Harrison; Janet M Lord Journal: Ann Surg Date: 2017-06 Impact factor: 12.969
Authors: Jennifer A Muszynski; Ryan Nofziger; Kristin Greathouse; Jyotsna Nateri; Lisa Hanson-Huber; Lisa Steele; Kathleen Nicol; Jonathan I Groner; Gail E Besner; Corey Raffel; Susan Geyer; Osama El-Assal; Mark W Hall Journal: Shock Date: 2014-10 Impact factor: 3.454
Authors: Julia A Penatzer; Robin Alexander; Shan Simon; Amber Wolfe; Julie Breuer; Josey Hensley; Renata Fabia; Mark Hall; Rajan K Thakkar Journal: Front Immunol Date: 2022-07-26 Impact factor: 8.786