Literature DB >> 2953123

Evidence for the intercalation of thalidomide into DNA: clue to the molecular mechanism of thalidomide teratogenicity?

H P Koch, M J Czejka.   

Abstract

The intercalation of thalidomide (alpha-phthalimidoglutarimide) into nucleic acids was studied by spectrophotometric titrations, displacement of known intercalators, viscosity changes of DNA solutions, and by phase partition analysis. Specific binding of thalidomide was found to DNA of various specimens (human placenta, calf thymus, salmon sperm), but not to RNA (from bakers yeast, torula yeast).

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Year:  1986        PMID： 2953123

Source DB:  PubMed          Journal:  Z Naturforsch C J Biosci        ISSN： 0341-0382


  3 in total

Review 1.  Thalidomide-type teratogenicity: structure-activity relationships for congeners.

Authors:  R L Smith; S C Mitchell
Journal:  Toxicol Res (Camb)       Date:  2018-09-26       Impact factor: 3.524

2.  Effects of oral thalidomide on rat liver and skin microsomal P450 isozyme activities and on urinary porphyrin excretion: interaction with oral hexachlorobenzene.

Authors:  D Tsambaos; K Bolsen; S Georgiou; A Monastirli; G Goerz
Journal:  Arch Dermatol Res       Date:  1994       Impact factor: 3.017

3.  In Vitro and In Vivo Antitumor Activity of Indolo[2,3-b] Quinolines, Natural Product Analogs from Neocryptolepine Alkaloid.

Authors:  Najla Altwaijry; Samah El-Ghlban; Ibrahim E-T El Sayed; Mohamed El-Bahnsawye; Asmaa I Bayomi; Rehab M Samaka; Elkhabiry Shaban; Elshaymaa I Elmongy; Thanaa A El-Masry; Hytham M A Ahmed; Nashwah G M Attallah
Journal:  Molecules       Date:  2021-02-01       Impact factor: 4.411
  3 in total

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