| Literature DB >> 29531160 |
Fanxin Zeng1,2, Xiao Chen3, Weiyi Cui1,2, Wei Wen1,2, Fujian Lu1, Xueting Sun1,2, Dongwei Ma1,2, Ye Yuan1,2, Zezhong Li1,2, Ning Hou1,2, Hong Zhao3, Xinyu Bi3, Jianjun Zhao3, Jianguo Zhou3, Yan Zhang1,2,4, Rui-Ping Xiao1,2,4, Jianqiang Cai5, Xiuqin Zhang6,2.
Abstract
The receptor-interacting protein kinase 1 (RIPK1) is an essential signaling molecule in pathways for cell survival, apoptosis, and necroptosis. We report here that RIPK1 is upregulated in human colorectal cancer and promotes cell proliferation when overexpressed in a colon cancer cell line. RIPK1 interacts with mitochondrial Ca2+ uniporter (MCU) to promote proliferation by increasing mitochondrial Ca2+ uptake and energy metabolism. The ubiquitination site of RIPK1 (RIPK1-K377) was critical for this interaction with MCU and function in promoting cell proliferation. These findings identify the RIPK1-MCU pathway as a promising target to treat colorectal cancer.Significance: RIPK1-mediated cell proliferation through MCU is a central mechanism underlying colorectal cancer progression and may prove to be an important therapeutic target for colorectal cancer treatment. Cancer Res; 78(11); 2876-85. ©2018 AACR. ©2018 American Association for Cancer Research.Entities:
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Year: 2018 PMID： 29531160 DOI： 10.1158/0008-5472.CAN-17-3082
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701