Hao-Ming Li1, Ying-Kai Huang1, Yuan-Chih Su1, Chia-Hung Kao2. 1. Department of Radiology (Li), E-Da Hospital; Department of Radiology (Huang), Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung, Taiwan; Management Office for Health Data (Su) and Department of Nuclear Medicine and PET Center (Kao), China Medical University Hospital; College of Medicine (Su) and Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine (Kao), China Medical University; Department of Bioinformatics and Medical Engineering (Kao), Asia University, Taichung, Taiwan. 2. Department of Radiology (Li), E-Da Hospital; Department of Radiology (Huang), Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung, Taiwan; Management Office for Health Data (Su) and Department of Nuclear Medicine and PET Center (Kao), China Medical University Hospital; College of Medicine (Su) and Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine (Kao), China Medical University; Department of Bioinformatics and Medical Engineering (Kao), Asia University, Taichung, Taiwan d10040@mail.cmuh.org.tw.
Abstract
BACKGROUND: Stroke is a severe neurologic complication of dengue fever, described in only a few case reports. The incidence and risk factors for stroke in patients with dengue remain unclear. We conducted a population-based retrospective cohort study to investigate the risk of stroke in patients with dengue. METHODS: Using data from the Taiwan National Health Insurance Research Database, we included a total of 13 787 patients with dengue newly diagnosed between 2000 and 2012. The control cohort consisted of patients who did not have dengue, matched 1:1 by demographic characteristics and stroke-related comorbidities. We calculated the cumulative incidences and hazard ratios (HRs) of stroke in both cohorts using Kaplan-Meier curves and Cox proportional hazards regression. RESULTS: The overall incidence rate of stroke was 5.33 per 1000 person-years in the dengue cohort and 3.72 per 1000 person-years in the control cohort, with an adjusted HR of 1.16 (95% confidence interval [CI] 1.01-1.32). The risk of stroke among patients with dengue was highest in the first 2 months after diagnosis (25.53 per 1000 person-years, adjusted HR 2.49, 95% CI 1.48-4.18). INTERPRETATION: Dengue fever was associated with an increased risk of stroke in the first few months after diagnosis. The effect of dengue on stroke may be acute rather than chronic.
BACKGROUND:Stroke is a severe neurologic complication of dengue fever, described in only a few case reports. The incidence and risk factors for stroke in patients with dengue remain unclear. We conducted a population-based retrospective cohort study to investigate the risk of stroke in patients with dengue. METHODS: Using data from the Taiwan National Health Insurance Research Database, we included a total of 13 787 patients with dengue newly diagnosed between 2000 and 2012. The control cohort consisted of patients who did not have dengue, matched 1:1 by demographic characteristics and stroke-related comorbidities. We calculated the cumulative incidences and hazard ratios (HRs) of stroke in both cohorts using Kaplan-Meier curves and Cox proportional hazards regression. RESULTS: The overall incidence rate of stroke was 5.33 per 1000 person-years in the dengue cohort and 3.72 per 1000 person-years in the control cohort, with an adjusted HR of 1.16 (95% confidence interval [CI] 1.01-1.32). The risk of stroke among patients with dengue was highest in the first 2 months after diagnosis (25.53 per 1000 person-years, adjusted HR 2.49, 95% CI 1.48-4.18). INTERPRETATION:Dengue fever was associated with an increased risk of stroke in the first few months after diagnosis. The effect of dengue on stroke may be acute rather than chronic.
Authors: Mitchell S V Elkind; Cara L Carty; Ellen S O'Meara; Thomas Lumley; David Lefkowitz; Richard A Kronmal; W T Longstreth Journal: Stroke Date: 2011-05-05 Impact factor: 7.914
Authors: Maria Lúcia Brito Ferreira; Maria de Fatima Pessoa Militão de Albuquerque; Carlos Alexandre Antunes de Brito; Rafael Freitas de Oliveira França; Álvaro José Porto Moreira; Maria Íris de Morais Machado; Roberta da Paz Melo; Raquel Medialdea-Carrera; Solange Dornelas Mesquita; Marcela Lopes Santos; Ravi Mehta; Rafael Ramos E Silva; Sonja E Leonhard; Mark Ellul; Anna Rosala-Hallas; Girvan Burnside; Lance Turtle; Michael J Griffiths; Bart C Jacobs; Maneesh Bhojak; Hugh J Willison; Lindomar José Pena; Carlos A Pardo; Ricardo A A Ximenes; Celina Maria Turchi Martelli; David W G Brown; Marli Tenório Cordeiro; Suzannah Lant; Tom Solomon Journal: Lancet Neurol Date: 2020-09-16 Impact factor: 59.935