Literature DB >> 29529708

An optimized radiosynthesis of [18 F]FNDP, a positron emission tomography radiotracer for imaging soluble epoxide hydrolase (sEH).

Babak Behnam Azad1, Daniel P Holt1, Hayden T Ravert1, Andrew G Horti1, Robert F Dannals1.   

Abstract

In this concise practitioner protocol, the radiochemical synthesis of [18 F]FNDP suitable for human positron emission tomography studies is described and the results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice requirements.
Copyright © 2018 John Wiley & Sons, Ltd.

Entities:  

Keywords:  Brain Disorders; Hypertension; Pracitioner Protocol; Soluble Epoxide Hydrolase

Mesh：

Substances：

Year:  2018        PMID： 29529708      PMCID： PMC6574083          DOI： 10.1002/jlcr.3620

Source DB:  PubMed          Journal:  J Labelled Comp Radiopharm        ISSN： 0362-4803            Impact factor:   1.921


  12 in total

1.  Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study.

Authors:  Craig R Lee; Kari E North; Molly S Bray; Myriam Fornage; John M Seubert; John W Newman; Bruce D Hammock; David J Couper; Gerardo Heiss; Darryl C Zeldin
Journal:  Hum Mol Genet       Date:  2006-04-04       Impact factor: 6.150

2.  Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates MPTP-Induced Parkinsonism.

Authors:  Xiaocui Qin; Qiaoqi Wu; Lifang Lin; Aimin Sun; Shuhu Liu; Xiaowen Li; Xiong Cao; Tianming Gao; Pengcheng Luo; Xinhong Zhu; Xuemin Wang
Journal:  Mol Neurobiol       Date:  2014-08-17       Impact factor: 5.590

3.  Role of soluble epoxide hydrolase in age-related vascular cognitive decline.

Authors:  Jonathan W Nelson; Jennifer M Young; Rohan N Borkar; Randy L Woltjer; Joseph F Quinn; Lisa C Silbert; Marjorie R Grafe; Nabil J Alkayed
Journal:  Prostaglandins Other Lipid Mediat       Date:  2014-09-30       Impact factor: 3.072

4.  Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy.

Authors:  Yu-Wen Hung; Shao-Wen Hung; Yi-Chen Wu; Lin-King Wong; Ming-Tsong Lai; Yang-Hsin Shih; Tzong-Shyuan Lee; Yung-Yang Lin
Journal:  Brain Behav Immun       Date:  2014-08-15       Impact factor: 7.217

5.  Distribution of soluble epoxide hydrolase, cytochrome P450 2C8, 2C9 and 2J2 in human malignant neoplasms.

Authors:  Ahmed E Enayetallah; Richard A French; David F Grant
Journal:  J Mol Histol       Date:  2006-09-07       Impact factor: 2.611

6.  A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion.

Authors:  Hayden T Ravert; Daniel P Holt; Robert F Dannals
Journal:  J Labelled Comp Radiopharm       Date:  2014-10-20       Impact factor: 1.921

Review 7.  Epoxide hydrolases: their roles and interactions with lipid metabolism.

Authors:  John W Newman; Christophe Morisseau; Bruce D Hammock
Journal:  Prog Lipid Res       Date:  2005-01-25       Impact factor: 16.195

8.  Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism.

Authors:  A Marowsky; J Burgener; J R Falck; J-M Fritschy; M Arand
Journal:  Neuroscience       Date:  2009-06-18       Impact factor: 3.590

9.  Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels.

Authors:  Jeffrey J Iliff; Ruikang Wang; Darryl C Zeldin; Nabil J Alkayed
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-03-20       Impact factor: 4.733

10.  18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase.

Authors:  Andrew G Horti; Yuchuan Wang; Il Minn; Xi Lan; Jian Wang; Raymond C Koehler; Nabil J Alkayed; Robert F Dannals; Martin G Pomper
Journal:  J Nucl Med       Date:  2016-07-14       Impact factor: 10.057
View more
  2 in total

1.  Radiosynthesis and validation of [Carboxy-11 C]4-Aminobenzoic acid ([11 C]PABA), a PET radiotracer for imaging bacterial infections.

Authors:  Daniel P Holt; Alvin S Kalinda; Lauren E Bambarger; Sanjay K Jain; Robert F Dannals
Journal:  J Labelled Comp Radiopharm       Date:  2018-08-29       Impact factor: 1.921

2.  PET imaging of soluble epoxide hydrolase in non-human primate brain with [18F]FNDP.

Authors:  Yong Du; Il Minn; Catherine Foss; Wojciech G Lesniak; Feng Hu; Robert F Dannals; Martin G Pomper; Andrew G Horti
Journal:  EJNMMI Res       Date:  2020-06-22       Impact factor: 3.138
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.