Lauren A Demers1, Kelly Jedd McKenzie2, Ruskin H Hunt2, Dante Cicchetti3, Raquel A Cowell4, Fred A Rogosch5, Sheree L Toth5, Kathleen M Thomas2. 1. Institute of Child Development, University of Minnesota, Minneapolis, Minnesota. Electronic address: demer048@umn.edu. 2. Institute of Child Development, University of Minnesota, Minneapolis, Minnesota. 3. Institute of Child Development, University of Minnesota, Minneapolis, Minnesota; Mount Hope Family Center, University of Rochester, Rochester, Minnesota. 4. Institute of Child Development, University of Minnesota, Minneapolis, Minnesota; St. Norbert College, De Pere, Wisconsin. 5. Mount Hope Family Center, University of Rochester, Rochester, Minnesota.
Abstract
BACKGROUND: Individuals with a history of maltreatment show altered amygdala reactivity to emotional stimuli, atypical frontal regulatory control, and differences in frontolimbic connectivity compared with nonmaltreated controls. However, despite early trauma, many individuals who experience maltreatment show resilience or adaptive functioning in adulthood including positive social, educational, and occupational outcomes. METHODS: The present study used a psychophysiological interaction model to examine the effect of adult adaptive functioning on group differences between maltreated and nonmaltreated adults in task-based amygdala functional connectivity. The task used was a facial emotion-matching paradigm. Functional magnetic resonance imaging scans were collected from 41 adults with a history of substantiated childhood maltreatment and 39 nonmaltreated adults who were well matched on demographic variables, all of whom had been studied since childhood. Adaptive functioning was measured with a composite score of success on stage-salient developmental tasks. RESULTS: Consistent with previous research, we found differences in task-related amygdala functional connectivity between the maltreated and nonmaltreated groups. Effects were seen in the left hippocampus, right dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, and right thalamus. However, when adult functioning was included in the model, maltreatment-related differences in amygdala connectivity were observed only in the hippocampus. Adult adaptive functioning independently predicted task-related amygdala connectivity in frontal and parietal regions across the entire sample. CONCLUSIONS: These results suggest that frontolimbic functional connectivity is predicted by positive developmental adaptation in this high-risk population, regardless of maltreatment history, whereas intralimbic connectivity (amygdala and hippocampus) is more specifically associated with maltreatment history.
BACKGROUND: Individuals with a history of maltreatment show altered amygdala reactivity to emotional stimuli, atypical frontal regulatory control, and differences in frontolimbic connectivity compared with nonmaltreated controls. However, despite early trauma, many individuals who experience maltreatment show resilience or adaptive functioning in adulthood including positive social, educational, and occupational outcomes. METHODS: The present study used a psychophysiological interaction model to examine the effect of adult adaptive functioning on group differences between maltreated and nonmaltreated adults in task-based amygdala functional connectivity. The task used was a facial emotion-matching paradigm. Functional magnetic resonance imaging scans were collected from 41 adults with a history of substantiated childhood maltreatment and 39 nonmaltreated adults who were well matched on demographic variables, all of whom had been studied since childhood. Adaptive functioning was measured with a composite score of success on stage-salient developmental tasks. RESULTS: Consistent with previous research, we found differences in task-related amygdala functional connectivity between the maltreated and nonmaltreated groups. Effects were seen in the left hippocampus, right dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, and right thalamus. However, when adult functioning was included in the model, maltreatment-related differences in amygdala connectivity were observed only in the hippocampus. Adult adaptive functioning independently predicted task-related amygdala connectivity in frontal and parietal regions across the entire sample. CONCLUSIONS: These results suggest that frontolimbic functional connectivity is predicted by positive developmental adaptation in this high-risk population, regardless of maltreatment history, whereas intralimbic connectivity (amygdala and hippocampus) is more specifically associated with maltreatment history.
Authors: Steven J A van der Werff; J Nienke Pannekoek; Ilya M Veer; Marie-José van Tol; André Aleman; Dick J Veltman; Frans G Zitman; Serge A R B Rombouts; Bernet M Elzinga; Nic J A van der Wee Journal: Child Abuse Negl Date: 2013-08-12
Authors: Anne-Laura van Harmelen; Marie-José van Tol; Nic J A van der Wee; Dick J Veltman; André Aleman; Philip Spinhoven; Mark A van Buchem; Frans G Zitman; Brenda W J H Penninx; Bernet M Elzinga Journal: Biol Psychiatry Date: 2010-08-08 Impact factor: 13.382
Authors: Mark Jenkinson; Christian F Beckmann; Timothy E J Behrens; Mark W Woolrich; Stephen M Smith Journal: Neuroimage Date: 2011-09-16 Impact factor: 6.556
Authors: Arash Javanbakht; Anthony P King; Gary W Evans; James E Swain; Michael Angstadt; K Luan Phan; Israel Liberzon Journal: Front Behav Neurosci Date: 2015-06-12 Impact factor: 3.558
Authors: Jill X O'Reilly; Mark W Woolrich; Timothy E J Behrens; Stephen M Smith; Heidi Johansen-Berg Journal: Soc Cogn Affect Neurosci Date: 2012-05-07 Impact factor: 3.436
Authors: Charlis Raineki; Maya Opendak; Emma Sarro; Ashleigh Showler; Kevin Bui; Bruce S McEwen; Donald A Wilson; Regina M Sullivan Journal: Proc Natl Acad Sci U S A Date: 2019-10-21 Impact factor: 11.205
Authors: Lauren A Demers; Elizabeth D Handley; Ruskin H Hunt; Fred A Rogosch; Sheree L Toth; Kathleen M Thomas; Dante Cicchetti Journal: Child Maltreat Date: 2019-05-13
Authors: Catherine Cerulli; Dante Cicchetti; Elizabeth D Handley; Jody Todd Manly; Fred A Rogosch; Sheree L Toth Journal: Dev Psychopathol Date: 2021-05
Authors: Lauren A Demers; Ruskin H Hunt; Dante Cicchetti; Julia E Cohen-Gilbert; Fred A Rogosch; Sheree L Toth; Kathleen M Thomas Journal: Dev Psychopathol Date: 2021-04-08