| Literature DB >> 29528633 |
Yevhen A Skalenko1,2, Tetiana V Druzhenko1,2, Aleksandr V Denisenko1,3, Maryna V Samoilenko1, Oleksandr P Dacenko1, Serhii A Trofymchuk1, Oleksandr O Grygorenko1,3, Andrey A Tolmachev1,3, Pavel K Mykhailiuk1,3.
Abstract
A one-step synthesis of functionalized 3-azabicyclo[3.2.0]heptanes by [2+2]-photochemical intermolecular cycloaddition of N-benzylmaleimide to alkenes was elaborated. The obtained compounds were easily transformed into the bi- and tricyclic analogues of piperidine, morpholine, piperazine, and GABA, which are advanced building blocks for drug discovery.Entities:
Year: 2018 PMID： 29528633 DOI： 10.1021/acs.joc.8b00077
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354