| Literature DB >> 29528417 |
Victoria P Strouvelle1,2, Dominique L Braun1,2, Valentina Vongrad1,2, Alexandra U Scherrer1, Yik Lim Kok1,2, Roger D Kouyos1,2, Marcel Stöckle3, Andri Rauch4, Katharine Darling5, Matthias Hoffmann6, Karin J Metzner1,2, Huldrych F Günthard1,2.
Abstract
Pegylated interferon-alpha (pIFN-α) is suggested to lower human immunodeficiency virus type-1 (HIV-1) DNA load in antiretroviral therapy (ART)-treated patients. We studied kinetics of HIV-1 DNA levels in 40 HIV-1/hepatitis C virus (HCV) coinfected patients, treated with pIFN-α for HCV and categorized into 3 groups according to start of ART: chronic HIV-1 infection (n = 22), acute HIV-1 infection (n = 8), no-ART (n = 10). Total HIV-1 DNA levels in 247 peripheral blood mononuclear cell samples were stable before, during, and after pIFN-α treatment in all groups. Our results question the benefit of pIFN-α as an immunotherapeutic agent for reducing the HIV-1 reservoir.Entities:
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Year: 2018 PMID： 29528417 DOI： 10.1093/infdis/jiy131
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 7.759