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Literature DB >> 29527821

On the relationship status for Arf and NPM1 - it's complicated.

Diana M Mitrea¹, Richard W Kriwacki^1,2.

Abstract

Arf levels are tightly regulated in cells and correlate with the level of ribosome biogenesis and proliferative status of cells. Through multivalent interactions with NPM1 - a regulator of ribosome biogenesis, and Mdm2 - a regulator of cellular fate, Arf integrates within the nucleolar matrix, altering its structure, dynamics and function and therefore modulates the cell cycle.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2018 PMID： 29527821 PMCID： PMC5965676 DOI： 10.1111/febs.14407

Source DB: PubMed Journal: FEBS J ISSN： 1742-464X Impact factor: 5.542

21 in total

Review 1. Translational control in cancer.

Authors: Deborah Silvera; Silvia C Formenti; Robert J Schneider
Journal: Nat Rev Cancer Date: 2010-04 Impact factor: 60.716

2. p53-independent functions of the p19(ARF) tumor suppressor.

Authors: J D Weber; J R Jeffers; J E Rehg; D H Randle; G Lozano; M F Roussel; C J Sherr; G P Zambetti
Journal: Genes Dev Date: 2000-09-15 Impact factor: 11.361

3. Defining the molecular basis of Arf and Hdm2 interactions.

Authors: B Bothner; W S Lewis; E L DiGiammarino; J D Weber; S J Bothner; R W Kriwacki
Journal: J Mol Biol Date: 2001-11-23 Impact factor: 5.469

4. Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization.

Authors: M A Lohrum; M Ashcroft; M H Kubbutat; K H Vousden
Journal: Curr Biol Date: 2000-05-04 Impact factor: 10.834

5. Structural polymorphism in the N-terminal oligomerization domain of NPM1.

Authors: Diana M Mitrea; Christy R Grace; Marija Buljan; Mi-Kyung Yun; Nicholas J Pytel; John Satumba; Amanda Nourse; Cheon-Gil Park; M Madan Babu; Stephen W White; Richard W Kriwacki
Journal: Proc Natl Acad Sci U S A Date: 2014-03-10 Impact factor: 11.205

6. Identification of a novel nucleophosmin-interaction motif in the tumor suppressor p14arf.

Authors: Enrico Luchinat; Sara Chiarella; Mimma Franceschini; Adele Di Matteo; Maurizio Brunori; Lucia Banci; Luca Federici
Journal: FEBS J Date: 2018-01-15 Impact factor: 5.542

7. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

Authors: T Kamijo; F Zindy; M F Roussel; D E Quelle; J R Downing; R A Ashmun; G Grosveld; C J Sherr
Journal: Cell Date: 1997-11-28 Impact factor: 41.582

8. Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23.

Authors: David Bertwistle; Masataka Sugimoto; Charles J Sherr
Journal: Mol Cell Biol Date: 2004-02 Impact factor: 4.272

9. A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function.

Authors: Anthony J Apicelli; Leonard B Maggi; Angela C Hirbe; Alexander P Miceli; Mary E Olanich; Crystal L Schulte-Winkeler; Anthony J Saporita; Michael Kuchenreuther; José Sanchez; Katherine Weilbaecher; Jason D Weber
Journal: Mol Cell Biol Date: 2007-12-10 Impact factor: 4.272

10. Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.

Authors: Diana M Mitrea; Jaclyn A Cika; Clifford S Guy; David Ban; Priya R Banerjee; Christopher B Stanley; Amanda Nourse; Ashok A Deniz; Richard W Kriwacki
Journal: Elife Date: 2016-02-02 Impact factor: 8.140

6 in total

On the relationship status for Arf and NPM1 - it's complicated.

Review 1. Translational control in cancer.

2. p53-independent functions of the p19(ARF) tumor suppressor.

3. Defining the molecular basis of Arf and Hdm2 interactions.

4. Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization.

5. Structural polymorphism in the N-terminal oligomerization domain of NPM1.

6. Identification of a novel nucleophosmin-interaction motif in the tumor suppressor p14arf.

7. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

8. Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23.

9. A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function.

10. Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.

Review 1. Nucleophosmin in Its Interaction with Ligands.

2. NSC348884 cytotoxicity is not mediated by inhibition of nucleophosmin oligomerization.

Review 3. Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy.

Review 4. The nucleolus, an ally, and an enemy of cancer cells.

5. Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies.

6. Next-generation sequencing in two cases of de novo acute basophilic leukaemia.