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Literature DB >> 2952721

Inhibition of suppressor T lymphocytes (Ts) by cimetidine.

D M Sahasrabudhe, C S McCune, R W O'Donnell, E C Henshaw.

Abstract

Cyclophosphamide (CY) is the most extensively studied inhibitor of suppressor T lymphocyte (Ts) function. However, repeated administration of CY can abrogate sensitization. Therefore, we were interested in identifying noncytotoxic inhibitors of Ts function as adjuncts in the immunotherapy of Ts-inducing murine tumors. The effect of cimetidine (a histamine type 2 receptor antagonist) and diphenhydramine (a histamine type 1 receptor antagonist) on the Ts mediating tolerance to 2,4-dinitrofluorobenzene was studied. We report our data regarding the specific inhibition of Ts by cimetidine.

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Year: 1987 PMID： 2952721

Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422

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Cited

16 in total

1. Immunomodulating effects of T-44 in comparison to HWA 486.

Authors: K Schmidt; H Bekemeier; J Giessler; H Pilopp
Journal: Agents Actions Date: 1991-01

Review 2. Haematological adverse effects of histamine H2-receptor antagonists.

Authors: J P Aymard; B Aymard; P Netter; B Bannwarth; P Trechot; F Streiff
Journal: Med Toxicol Adverse Drug Exp Date: 1988 Nov-Dec

3. The relationship between clinical stage, natural killer activity and related immunological parameters in adenocarcinoma of the prostate.

Authors: N Lahat; B Alexander; D R Levin; B Moskovitz
Journal: Cancer Immunol Immunother Date: 1989 Impact factor: 6.968

4. Possible involvement of adenosine 3':5'-cyclic monophosphate and extracellular calcium ions in histamine stimulation of interleukin-1 release from macrophage-like P388D1 cells.

Authors: H Okamoto; C Oh; K Nakano
Journal: Immunology Date: 1990-06 Impact factor: 7.397

10. Inhibition of T suppressor cell function by local administration of an active cyclophosphamide derivative at the sensitization site.

Authors: J Limpens; R J Scheper
Journal: Clin Exp Immunol Date: 1991-06 Impact factor: 4.330

Inhibition of suppressor T lymphocytes (Ts) by cimetidine.

1. Immunomodulating effects of T-44 in comparison to HWA 486.

Review 2. Haematological adverse effects of histamine H2-receptor antagonists.

3. The relationship between clinical stage, natural killer activity and related immunological parameters in adenocarcinoma of the prostate.

4. Possible involvement of adenosine 3':5'-cyclic monophosphate and extracellular calcium ions in histamine stimulation of interleukin-1 release from macrophage-like P388D1 cells.

5. Synergistic antitumor activity of interleukin-2 and cimetidine against syngeneic murine tumor.

Review 6. Histamine2 (H2)-receptor antagonists in the treatment of urticaria.

7. Repurposing cimetidine for cholangiocarcinoma: Antitumor effects in vitro and in vivo.

Review 8. How type I interferons work in multiple sclerosis and other diseases: some unexpected mechanisms.

9. Cimetidine as modulator of the cell-mediated immune response in vivo using the tuberculin skin test as parameter.

10. Inhibition of T suppressor cell function by local administration of an active cyclophosphamide derivative at the sensitization site.