| Literature DB >> 29526575 |
Júnior Mário Baltazar de Oliveira1, Jonatas Campos de Almeida2, Renata Pimentel Bandeira de Melo2, Luiz Daniel de Barros3, João Luis Garcia3, Müller Ribeiro Andrade2, Wagnner José Nascimento Porto4, Javier Regidor-Cerrillo5, Luis Miguel Ortega-Mora5, Andréa Alice da Fonseca Oliveira2, Rinaldo Aparecido Mota2.
Abstract
The purpose of this study was to perform genotypic characterization and to evaluate the virulence of Toxoplasma gondii obtained from aborted fetuses in an abortion outbreak in goats from northeastern Brazil. Brain samples from 32 fetuses were submitted to mouse bioassay for T. gondii isolation. Two isolates were obtained and subjected to genotypic characterization. Isolate virulence was evaluated using murine model in different doses (from 105 to 101 tachyzoites/mL). In genotyping, both isolates were classified as clonal lineage type II (genotype #1 ToxoDB) and showed to be virulent for mice. This is the first description of genotype #1 in cases of goat abortion, showing the circulation of virulent T. gondii isolate producing reproductive disorders in pregnant goat.Entities:
Keywords: Genotyping; Goat; Reproductive disorders; Toxoplasmosis; Virulence
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Year: 2018 PMID： 29526575 DOI： 10.1016/j.exppara.2018.03.008
Source DB: PubMed Journal: Exp Parasitol ISSN： 0014-4894 Impact factor: 2.011