Ling Chen1, Yufeng Li2, Fang Zhang3, Simin Zhang4, Xianghai Zhou5, Linong Ji6. 1. Department of Endocrinology and Metabolism, Peking University People's Hospital, The 11th South Street, Xicheng, Beijing, China. Electronic address: chenling19841227@163.com. 2. Department of Endocrinology and Metabolism, Peking University People's Hospital, The 11th South Street, Xicheng, Beijing, China; Department of Endocrinology and Metabolism, Pinggu Hospital, The 59th Xinping North Road, Pinggu, Beijing, China. Electronic address: doctorlyf@126.com. 3. Department of Endocrinology and Metabolism, Peking University People's Hospital, The 11th South Street, Xicheng, Beijing, China. Electronic address: zhangfang87@outlook.com. 4. Department of Endocrinology and Metabolism, Peking University People's Hospital, The 11th South Street, Xicheng, Beijing, China. Electronic address: november619@hotmail.com. 5. Department of Endocrinology and Metabolism, Peking University People's Hospital, The 11th South Street, Xicheng, Beijing, China. Electronic address: xianghaizhou1@163.com. 6. Department of Endocrinology and Metabolism, Peking University People's Hospital, The 11th South Street, Xicheng, Beijing, China. Electronic address: jiln@bjmu.edu.cn.
Abstract
AIMS: We aimed to evaluate the association between serum ferritin levels and incident type 2 diabetes mellitus risk in a Chinese population. METHODS: This cohort study assessed 2225 Chinese individuals aged 25-75 years. Diabetes mellitus was diagnosed using the 1999 World Health Organization definition with a median follow-up period of 20 months. Cox proportional hazard models were used to estimate adjusted hazard ratios and 95% confidence intervals (CI) for incident diabetes when serum ferritin concentrations increased by one standard deviation. RESULTS: During the follow-up period, 112 cases (62 men and 50 women) of type 2 diabetes mellitus were identified. Baseline serum ferritin levels were higher in the diabetes than the non-diabetes group. After adjusting for age, body mass index, waist circumference, mean arterial pressure, fasting plasma glucose, fasting insulin, hemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol, alanine transaminase and triglyceride levels, family history of diabetes mellitus, pork meat consumption, neutrophil/lymphocyte ratio, education, and annual household income, the hazard ratios for incident diabetes corresponding to one standard deviation increase in serum ferritin levels were 1.17 (95% CI 1.03, 1.34), 1.20 (95% CI 1.003, 1.43), and 1.03 (95% CI 0.82, 1.31) for the total population, men, and women, respectively. CONCLUSIONS: High serum ferritin levels were associated with a higher risk of incident type 2 diabetes mellitus independent of traditional risk factors in the total population and men.
AIMS: We aimed to evaluate the association between serum ferritin levels and incident type 2 diabetes mellitus risk in a Chinese population. METHODS: This cohort study assessed 2225 Chinese individuals aged 25-75 years. Diabetes mellitus was diagnosed using the 1999 World Health Organization definition with a median follow-up period of 20 months. Cox proportional hazard models were used to estimate adjusted hazard ratios and 95% confidence intervals (CI) for incident diabetes when serum ferritin concentrations increased by one standard deviation. RESULTS: During the follow-up period, 112 cases (62 men and 50 women) of type 2 diabetes mellitus were identified. Baseline serum ferritin levels were higher in the diabetes than the non-diabetes group. After adjusting for age, body mass index, waist circumference, mean arterial pressure, fasting plasma glucose, fasting insulin, hemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol, alanine transaminase and triglyceride levels, family history of diabetes mellitus, pork meat consumption, neutrophil/lymphocyte ratio, education, and annual household income, the hazard ratios for incident diabetes corresponding to one standard deviation increase in serum ferritin levels were 1.17 (95% CI 1.03, 1.34), 1.20 (95% CI 1.003, 1.43), and 1.03 (95% CI 0.82, 1.31) for the total population, men, and women, respectively. CONCLUSIONS: High serum ferritin levels were associated with a higher risk of incident type 2 diabetes mellitus independent of traditional risk factors in the total population and men.
Authors: Laureane N Masi; Paulo A Lotufo; Frederico M Ferreira; Alice C Rodrigues; Tamires D A Serdan; Talita Souza-Siqueira; Aécio A Braga; Magda E G Saldarriaga; Tatiana C Alba-Loureiro; Fernanda T Borges; Diego P Cury; Mario H Hirata; Renata Gorjão; Tania C Pithon-Curi; Simão A Lottenberg; Ligia M G Fedeli; Helder T I Nakaya; Isabela J M Bensenor; Rui Curi; Sandro M Hirabara Journal: Physiol Rep Date: 2021-02
Authors: Juan Manuel Martínez-Soto; Maria Del Carmen Candia-Plata; Luis Fernando López-Soto; Jesús Adriana Soto-Guzmán; Alma Yolanda Camacho-Villa; Gerardo Álvarez-Hernández; Ana Lourdes Mata-Pineda; José Manuel Galván-Moroyoqui Journal: Heliyon Date: 2021-04-09