| Literature DB >> 29524179 |
Florencia Clément1, Ayelen Martin1, Marcela Venara1, Maria de Luján Calcagno2, Cecilia Mathó1, Silvana Maglio3, Mercedes García Lombardi4, Ignacio Bergadá1, Patricia A Pennisi5.
Abstract
Nuclear localization of insulin-like growth factor receptor type 1 (IGF-1R) has been described as adverse prognostic factor in some cancers. We studied the expression and localization of IGF-1R in paediatric patients with gliomas, as well as its association with World Health Organization (WHO) grading and survival. We conducted a single cohort, prospective study of paediatric patients with gliomas. Samples were taken at the time of the initial surgery; IGF-1R expression and localization were characterized by immunohistochemistry (IHC), subcellular fractionation and western blotting. Tumours (47/53) showed positive staining for IGF-1R by IHC. IGF-1R nuclear labelling was observed in 10/47 cases. IGF-1R staining was mostly non-nuclear in low-grade tumours, while IGF-1R nuclear labelling was predominant in high-grade gliomas (p = 0.0001). Survival was significantly longer in patients with gliomas having non-nuclear IGF-1R localization than in patients with nuclear IGF-1R tumours (p = 0.016). In gliomas, IGF-1R nuclear localization was significantly associated with both high-grade tumours and increased risk of death. Based on a prospective design, we provide evidence of a potential usefulness of intracellular localization of IGF-1R as prognostic factor in paediatric patients with gliomas.Entities:
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Year: 2018 PMID： 29524179 DOI： 10.1007/s12672-018-0328-7
Source DB: PubMed Journal: Horm Cancer ISSN： 1868-8497 Impact factor: 3.869