Sung Keun Park1, Jae-Hong Ryoo2, Chang-Mo Oh3, Joong-Myung Choi3, Ju Young Jung4. 1. Center for Cohort StudiesTotal Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 2. Department of Occupational and Environmental MedicineSchool of Medicine, Kyung Hee University, Seoul, Korea. 3. Department of Preventive MedicineSchool of Medicine, Kyung Hee University, Seoul, Korea. 4. Total Healthcare CenterSchool of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, Korea jjy0501@naver.com.
Abstract
BACKGROUND: Body fat plays the significant role in maintaining glucose homeostasis. However, it is not fully identified how body fat percentage (BF%) has an impact on the development of type 2 diabetes mellitus (T2DM). Thus, this study was to evaluate the incidental risk for T2DM according to BF% level. METHODS: In a community-based Korean cohort, 5972 Korean adults were divided into quintile groups by BF% and followed up for 10 years to monitor the development of T2DM. Cox proportional hazard model was used to evaluate the hazard ratios (HRs) for T2DM according to BF% quintile. Additionally, subgroup analysis was conducted by low and high level of BF% (cut-off: 25 in men and 35 in women) and body mass index (BMI). RESULTS: In adjusted model, compared to the BF% quintile 1 group, the risk for T2DM significantly increased over BF% of 22.8% in men and 32.9% in women (≥quintile 4). The level of BF% related to the increased risk for T2DM was lower in non-obese men (22.8%) than obese men (28.4%). In subgroup analysis, men with low BMI (<25) and high BF% (≥25) had the highest risk for T2DM than other subgroups (HRs: 1.83 (1.33-2.52)). However, this association did not show the statistical significance in women (HRs: 1.63 (0.98-2.72)). CONCLUSION: The incidental risk for T2DM significantly increased over the specific level of BF%, which was lower in non-obese population than obese population. Gender difference was suggested in the incidental relationship between BF% and T2DM.
BACKGROUND: Body fat plays the significant role in maintaining glucose homeostasis. However, it is not fully identified how body fat percentage (BF%) has an impact on the development of type 2 diabetes mellitus (T2DM). Thus, this study was to evaluate the incidental risk for T2DM according to BF% level. METHODS: In a community-based Korean cohort, 5972 Korean adults were divided into quintile groups by BF% and followed up for 10 years to monitor the development of T2DM. Cox proportional hazard model was used to evaluate the hazard ratios (HRs) for T2DM according to BF% quintile. Additionally, subgroup analysis was conducted by low and high level of BF% (cut-off: 25 in men and 35 in women) and body mass index (BMI). RESULTS: In adjusted model, compared to the BF% quintile 1 group, the risk for T2DM significantly increased over BF% of 22.8% in men and 32.9% in women (≥quintile 4). The level of BF% related to the increased risk for T2DM was lower in non-obesemen (22.8%) than obesemen (28.4%). In subgroup analysis, men with low BMI (<25) and high BF% (≥25) had the highest risk for T2DM than other subgroups (HRs: 1.83 (1.33-2.52)). However, this association did not show the statistical significance in women (HRs: 1.63 (0.98-2.72)). CONCLUSION: The incidental risk for T2DM significantly increased over the specific level of BF%, which was lower in non-obese population than obese population. Gender difference was suggested in the incidental relationship between BF% and T2DM.