Teddy Léguillier1, Romain Jouffroy2, Marie Boisson3, Agathe Boussaroque3, Camille Chenevier-Gobeaux4, Tarek Chaabouni5, Benoît Vivien2, Valérie Nivet-Antoine1, Jean-Louis Beaudeux6. 1. Department of Clinical Biochemistry, Necker Hospital, AP-HP, Paris, France; UMR-S1140, Paris Descartes University, Faculty of Pharmaceutical Sciences of Paris, France. 2. SAMU 75, Medical Intensive Care Unit, Necker Hospital, AP-HP, Paris, France; Paris Descartes University, Faculty of Medicine, Paris, France. 3. Department of Clinical Biochemistry, Necker Hospital, AP-HP, Paris, France. 4. Department of Automated Biological Diagnosis, Cochin Hospital, Hôpitaux Universitaires Paris Centre (HUPC), Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France. 5. Department of Clinical Biochemistry, Bichat-Claude Bernard Hospital, AP-HP, Paris, France. 6. Department of Clinical Biochemistry, Necker Hospital, AP-HP, Paris, France; UMR-S1139, Paris Descartes University, Faculty of Pharmaceutical Sciences of Paris, France. Electronic address: jean-louis.beaudeux@inserm.fr.
Abstract
AIM OF THE STUDY: We evaluated if the StatStrip Xpress Meter, a Lactate point of care testing (POCT) handled device, could be a valuable tool in the mobile intensive care units (MICU) to assess the severity of septic patients. METHODS: We first investigated POCT analytical performance, then, using samples collected from 50 identified septic patients admitted to the intensive care unit (ICU), we compared lactate values obtained with the device to those obtained with four central laboratory analysers: one whole blood and three plasma-based methods. RESULTS: Results were compared by least squares regression, Bland-Altman plot and by comparing concordance within clinically relevant lactate ranges. We observed a reliable analytical performance of the POCT (CVs < 3.8% for repeatability and <5.0% for reproducibility) an excellent correlation between POCT and central laboratory analysers (R2: 0.96-0.98, slopes:0.83-0.90, intercepts: 0.02-0.03) and an excellent concordance of the POCT results to the central laboratory analyser results (98-100%). CONCLUSION: Whatever the methodology used, lactate values obtained are comparable and transferable between POCT and central laboratory analysers meaning that POCT could be a valuable tool in the MICU to evaluate the severity of septic patients and to better manage their hospital triage.
AIM OF THE STUDY: We evaluated if the StatStrip Xpress Meter, a Lactate point of care testing (POCT) handled device, could be a valuable tool in the mobile intensive care units (MICU) to assess the severity of septicpatients. METHODS: We first investigated POCT analytical performance, then, using samples collected from 50 identified septicpatients admitted to the intensive care unit (ICU), we compared lactate values obtained with the device to those obtained with four central laboratory analysers: one whole blood and three plasma-based methods. RESULTS: Results were compared by least squares regression, Bland-Altman plot and by comparing concordance within clinically relevant lactate ranges. We observed a reliable analytical performance of the POCT (CVs < 3.8% for repeatability and <5.0% for reproducibility) an excellent correlation between POCT and central laboratory analysers (R2: 0.96-0.98, slopes:0.83-0.90, intercepts: 0.02-0.03) and an excellent concordance of the POCT results to the central laboratory analyser results (98-100%). CONCLUSION: Whatever the methodology used, lactate values obtained are comparable and transferable between POCT and central laboratory analysers meaning that POCT could be a valuable tool in the MICU to evaluate the severity of septicpatients and to better manage their hospital triage.
Authors: Carl Magnusson; Johan Herlitz; Robert Höglind; Pär Wennberg; Anna Edelvik Tranberg; Christer Axelsson; Johan Zelano Journal: Epilepsia Date: 2021-01-08 Impact factor: 5.864