Tamas Daher1, Mehmet Kemal Tur1, Alexander Brobeil1, Benjamin Etschmann1, Biruta Witte2, Rita Engenhart-Cabillic3, Gabriele Krombach4, Wolfgang Blau5, Friedrich Grimminger5, Werner Seeger6, Jens Peter Klussmann7, Andreas Bräuninger1, Stefan Gattenlöhner1. 1. Institute of Pathology, University Hospital Giessen, Justus-Liebig-University Giessen, Giessen, Germany. 2. Department of General and Thoracic Surgery, University Hospital Giessen, Giessen, Germany. 3. Department of Radiation Therapy, University Hospital Giessen, Giessen, Germany. 4. Department of Diagnostic and Interventional Radiology, University Hospital Giessen, Justus-Liebig-University Giessen, Giessen, Germany. 5. Department of Internal Medicine V, University Hospital Giessen, Giessen, Germany. 6. Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany. 7. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen, Justus-Liebig-University Giessen, Giessen, Germany.
Abstract
BACKGROUND: In head and neck squamous cell carcinoma (HNSCC), the occurrence of concurrent lung malignancies poses a significant diagnostic challenge because metastatic HNSCC is difficult to discern from second primary lung squamous cell carcinoma (SCC). However, this differentiation is crucial because the recommended treatments for metastatic HNSCC and second primary lung SCC differ profoundly. METHODS: We analyzed the origin of lung tumors in 32 patients with HNSCC using human papillomavirus (HPV) typing and targeted next generation sequencing of all coding exons of tumor protein 53 (TP53). RESULTS: Lung tumors were clearly identified as HNSCC metastases or second primary tumors in 29 patients, thus revealing that 16 patients had received incorrect diagnoses based on clinical and morphological data alone. CONCLUSION: The HPV typing and mutation analysis of all TP53 coding exons is a valuable diagnostic tool in patients with HNSCC and concurrent lung SCC, which can help to ensure that patients receive the most suitable treatment.
BACKGROUND: In head and neck squamous cell carcinoma (HNSCC), the occurrence of concurrent lung malignancies poses a significant diagnostic challenge because metastatic HNSCC is difficult to discern from second primary lung squamous cell carcinoma (SCC). However, this differentiation is crucial because the recommended treatments for metastatic HNSCC and second primary lung SCC differ profoundly. METHODS: We analyzed the origin of lung tumors in 32 patients with HNSCC using human papillomavirus (HPV) typing and targeted next generation sequencing of all coding exons of tumor protein 53 (TP53). RESULTS:Lung tumors were clearly identified as HNSCC metastases or second primary tumors in 29 patients, thus revealing that 16 patients had received incorrect diagnoses based on clinical and morphological data alone. CONCLUSION: The HPV typing and mutation analysis of all TP53 coding exons is a valuable diagnostic tool in patients with HNSCC and concurrent lung SCC, which can help to ensure that patients receive the most suitable treatment.
Authors: Maja Šutić; Jurica Baranašić; Lana Kovač Bilić; Mario Bilić; Antonija Jakovčević; Luka Brčić; Sven Seiwerth; Marko Jakopović; Miroslav Samaržija; Ulrich Zechner; Jelena Knežević Journal: Diagn Pathol Date: 2021-02-26 Impact factor: 2.644