Literature DB >> 2952220

Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice.

E Roberts, L Bologa, J F Flood, G E Smith.   

Abstract

Low concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) enhanced neuronal and glial survival and/or differentiation in dissociated cultures of 14-day mouse embryo brain. Posttrial intracisternal injection into the brains of mice undergoing active avoidance training alleviated amnesia and enhanced long-term memory. By minimizing degenerative changes in injured nerve tissue and facilitating plastic changes, DHEA and DHEAS may be of use in treatment of neurodegenerative and memory disorders in man.

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Year:  1987        PMID： 2952220     DOI： 10.1016/0006-8993(87)90807-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  18 in total

1.  Effects of dehydroepiandrosterone sulfate on the evoked cortical activity of controls and of brain-injured rats.

Authors:  György Lür; Gabriella Rákos; Gabriella Juhász-Vedres; Tamás Farkas; Zsolt Kis; József Toldi
Journal:  Cell Mol Neurobiol       Date:  2006-06-07       Impact factor: 5.046

2.  Perimenopausal regulation of steroidogenesis in the nonhuman primate.

Authors:  Krystina G Sorwell; Steven G Kohama; Henryk F Urbanski
Journal:  Neurobiol Aging       Date:  2011-06-17       Impact factor: 4.673

Review 3.  Steroid control of higher brain function and behavior.

Authors:  S Mortaud; H Degrelle
Journal:  Behav Genet       Date:  1996-07       Impact factor: 2.805

Review 4.  Causes and consequences of age-related steroid hormone changes: insights gained from nonhuman primates.

Authors:  K G Sorwell; H F Urbanski
Journal:  J Neuroendocrinol       Date:  2013-11       Impact factor: 3.627

5.  Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive.

Authors:  J F Flood; J E Morley; E Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

6.  Dehydroepiandrosterone sulfate and cognitive function in the elderly: The InCHIANTI Study.

Authors:  G Valenti; L Ferrucci; F Lauretani; G Ceresini; S Bandinelli; M Luci; G Ceda; M Maggio; R S Schwartz
Journal:  J Endocrinol Invest       Date:  2009-10       Impact factor: 4.256

Review 7.  Neuroprotective actions of brain aromatase.

Authors:  Colin J Saldanha; Kelli A Duncan; Bradley J Walters
Journal:  Front Neuroendocrinol       Date:  2009-05-18       Impact factor: 8.606

8.  Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

Authors:  J F Flood; J E Morley; E Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205

9.  The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptors.

Authors:  L Zvejniece; E Vavers; B Svalbe; R Vilskersts; I Domracheva; M Vorona; G Veinberg; I Misane; I Stonans; I Kalvinsh; M Dambrova
Journal:  Br J Pharmacol       Date:  2014-02       Impact factor: 8.739

10.  The effects of galantamine hydrobromide treatment on dehydroepiandrosterone sulfate and cortisol levels in patients with chronic fatigue syndrome.

Authors:  Tayfun Turan; Hasan Basri Izgi; Saliha Ozsoy; Fatih Tanrıverdi; Mustafa Basturk; Akif Asdemir; Aslı Beşirli; Ertugrul Esel; Seher Sofuoglu
Journal:  Psychiatry Investig       Date:  2009-06-23       Impact factor: 2.505
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