Literature DB >> 29521227

VCP/p97/Cdc48, A Linking of Protein Homeostasis and Cancer Therapy.

B Lan1, S Chai2, P Wang1, K Wang1.   

Abstract

VCP/p97/Cdc48, a member of the ATPases associated with diverse cellular activities (AAA) family, is necessary for the endoplasmic-reticulum-associated protein degradation (ERAD) pathway to maintain protein homeostasis. Overwhelming proteotoxic stress drove cancer cells to enhance VCP/p97/Cdc48-associated ERAD to maintain protein homeostasis for survival, demonstrating that VCP/p97/Cdc48 expression was positively correlated with cancer prognosis. More studies revealed that targeting VCP/p97/Cdc48 could be a potential target in cancer therapy. CB-5083, a novel inhibitor of VCP/p97/Cdc48, is in clinical trials as the first VCP/p97/Cdc48- inhibiting drug for cancer therapy. Here, we discuss the relationship between VCP/p97/Cdc48, ERAD, protein homeostasis and cancer therapy. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  CB-5083; ER stress; ERAD; VCP/p97/Cdc48; cancer therapy; protein homeostasis.

Mesh：

Substances：

Year:  2017        PMID： 29521227     DOI： 10.2174/1566524018666180308111238

Source DB:  PubMed          Journal:  Curr Mol Med        ISSN： 1566-5240            Impact factor:   2.222


  14 in total

1.  VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.

Authors:  Khalid Arhzaouy; Chrisovalantis Papadopoulos; Nina Schulze; Sara K Pittman; Hemmo Meyer; Conrad C Weihl
Journal:  Autophagy       Date:  2019-01-29       Impact factor: 16.016

2.  Valosin-containing protein/p97 plays critical roles in the Japanese encephalitis virus life cycle.

Authors:  Sapna Sehrawat; Renu Khasa; Arundhati Deb; Surendra Kumar Prajapat; Suvadip Mallick; Anirban Basu; Milan Surjit; Manjula Kalia; Sudhanshu Vrati
Journal:  J Virol       Date:  2021-03-17       Impact factor: 5.103

3.  Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs.

Authors:  Amy K LeBlanc; Christina N Mazcko; Timothy M Fan; David M Vail; Brian K Flesner; Jeffrey N Bryan; Shan Li; Feng Wang; Scott Harris; Jesse D Vargas; Jeevan P Govindharajulu; Soumya Jaganathan; Francesca Tomaino; Apurva K Srivastava; Tsui-Fen Chou; Gordon M Stott; Joseph M Covey; Barbara Mroczkowski; James H Doroshow
Journal:  Mol Cancer Ther       Date:  2022-10-07       Impact factor: 6.009

4.  NMS-873 Leads to Dysfunctional Glycometabolism in A p97-Independent Manner in HCT116 Colon Cancer Cells.

Authors:  Shan Li; Feng Wang; Gang Zhang; Tsui-Fen Chou
Journal:  Pharmaceutics       Date:  2022-03-31       Impact factor: 6.525

5.  NMS-873 functions as a dual inhibitor of mitochondrial oxidative phosphorylation.

Authors:  Miranda F Bouwer; Kathryn E Hamilton; Patrick B Jonker; Sam R Kuiper; Larry L Louters; Brendan D Looyenga
Journal:  Biochimie       Date:  2021-03-13       Impact factor: 4.372

6.  Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction.

Authors:  Halley B Rycenga; Kelly B Wolfe; Elizabeth S Yeh; David T Long
Journal:  Sci Rep       Date:  2019-07-17       Impact factor: 4.379

7.  VCP/p97 controls signals of the ERK1/2 pathway transmitted via the Shoc2 scaffolding complex: novel insights into IBMPFD pathology.

Authors:  HyeIn Jang; Eun Ryoung Jang; Patricia G Wilson; Daniel Anderson; Emilia Galperin
Journal:  Mol Biol Cell       Date:  2019-05-15       Impact factor: 4.138

8.  Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST.

Authors:  Chang-In Moon; William Tompkins; Yuxi Wang; Abigail Godec; Xiaochun Zhang; Patrik Pipkorn; Christopher A Miller; Carina Dehner; Sonika Dahiya; Angela C Hirbe
Journal:  Genes (Basel)       Date:  2020-05-01       Impact factor: 4.096

Review 9.  Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities.

Authors:  Hongyang Shu; Yizhong Peng; Weijian Hang; Ning Zhou; Dao Wen Wang
Journal:  Biochem Soc Trans       Date:  2021-02-26       Impact factor: 5.407

Review 10.  Valosin-Containing Protein, a Calcium-Associated ATPase Protein, in Endoplasmic Reticulum and Mitochondrial Function and Its Implications for Diseases.

Authors:  Xiaonan Sun; Hongyu Qiu
Journal:  Int J Mol Sci       Date:  2020-05-28       Impact factor: 5.923
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