Fernanda Pedrotti Moreira1, Carolina David Wiener2, Karen Jansen1, Luis Valmor Portela3, Diogo R Lara4, Luciano Dias de Mattos Souza1, Ricardo Azevedo da Silva1, Jean Pierre Oses5. 1. Translational Science on Brain Disorders, Clinical Neuroscience Laboratory, Department of Health and Behavior, Catholic University of Pelotas, RS, Brazil. 2. Translational Science on Brain Disorders, Clinical Neuroscience Laboratory, Department of Health and Behavior, Catholic University of Pelotas, RS, Brazil; Anhanguera College of Rio Grande, RS, Brazil. Electronic address: carolinawiener@gmail.com. 3. Neurotrauma Laboratory, Department of Biochemistry, Institute of Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. 4. Neurochemistry and Psychopharmacology Laboratory, Cellular and Molecular Biology Department, Faculty of Bioscience, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil. 5. Translational Science on Brain Disorders, Clinical Neuroscience Laboratory, Department of Health and Behavior, Catholic University of Pelotas, RS, Brazil; Technology Application in Neurosciences, Department of Electronic Engineering and Computer, Catholic University of Pelotas, Brazil.
Abstract
OBJECTIVE: The aim of this study was to evaluate the effect of childhood trauma in cytokine serum levels of individuals with MDD. METHODS: This was a cross-sectional study population-based, with people aged 18 to 35. The Mini International Neuropsychiatric Interview (M.I.N.I) measured to current major depressive disorder (MDD). To evaluate traumatic experiences during childhood, the Childhood Trauma Questionnaire (CTQ) was applied. Serum TNF- α, IL-6 and IL-10 levels were measured by ELISA using a commercial kit. RESULTS: The total sample comprised 166 young adults, of these: 40.4% were subjects with MDD and childhood trauma and 59.6% were diagnosed with MDD without childhood trauma. In relation to serum interleukin levels, subjects with childhood trauma showed a significantly higher serum IL-6 (p = 0.013) and IL-10 levels (p = 0.022) to compare no childhood trauma. Subjects with childhood trauma was observed positive correlation between serum IL-6 and physical abuse (r = 0.232, p = 0.035) and emotional abuse (r = 0.460, p ≤ 0.001). Moreover, IL-10 were positive correlation with physical abuse (r = 0.258, p = 0.013). TNF- α was not associated with childhood trauma. CONCLUSION: Childhood maltreatment may result higher inflammation dysregulation in individuals with depression than individuals that no has childhood maltreatment.
OBJECTIVE: The aim of this study was to evaluate the effect of childhood trauma in cytokine serum levels of individuals with MDD. METHODS: This was a cross-sectional study population-based, with people aged 18 to 35. The Mini International Neuropsychiatric Interview (M.I.N.I) measured to current major depressive disorder (MDD). To evaluate traumatic experiences during childhood, the Childhood Trauma Questionnaire (CTQ) was applied. Serum TNF- α, IL-6 and IL-10 levels were measured by ELISA using a commercial kit. RESULTS: The total sample comprised 166 young adults, of these: 40.4% were subjects with MDD and childhood trauma and 59.6% were diagnosed with MDD without childhood trauma. In relation to serum interleukin levels, subjects with childhood trauma showed a significantly higher serum IL-6 (p = 0.013) and IL-10 levels (p = 0.022) to compare no childhood trauma. Subjects with childhood trauma was observed positive correlation between serum IL-6 and physical abuse (r = 0.232, p = 0.035) and emotional abuse (r = 0.460, p ≤ 0.001). Moreover, IL-10 were positive correlation with physical abuse (r = 0.258, p = 0.013). TNF- α was not associated with childhood trauma. CONCLUSION: Childhood maltreatment may result higher inflammation dysregulation in individuals with depression than individuals that no has childhood maltreatment.
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