| Literature DB >> 29518718 |
Huiyuan Zhao1, Cui Wang2, Nan Zhao1, Wenxue Li3, Zhaofei Yang4, Xinxin Liu1, Weidong Le5, Xiaozhe Zhang6.
Abstract
The plasma of Parkinson's disease (PD) patients may contain various altered metabolites associated with the risk or progression of the disease. Characterization of the abnormal metabolic pattern in PD plasma is therefore critical for the search for potential PD biomarkers. We collected blood plasma samples from PD patients and used an LC-MS based metabolomics approach to identify 17 metabolites with significantly altered levels. Metabolic network analysis was performed to place the metabolites linked to different pathways. The metabolic pathways involved were associated with tyrosine biosynthesis, glycerol phospholipid metabolism, carnitine metabolism and bile acid biosynthesis, within which carnitine and bile acid metabolites as potential biomarkers are first time reported. These abnormal metabolic changes in the plasma of patients with PD were mainly related to lipid metabolism and mitochondrial function.Entities:
Keywords: Metabolites; Metabolomics; Parkinson's disease; Pathway; Plasma
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Year: 2018 PMID： 29518718 DOI： 10.1016/j.jchromb.2018.01.025
Source DB: PubMed Journal: J Chromatogr B Analyt Technol Biomed Life Sci ISSN： 1570-0232 Impact factor: 3.205