Literature DB >> 29518538

Selectivity of probes for PET imaging of dopamine D3 receptors.

Robert K Doot1, Jacob G Dubroff2, Kyle J Labban2, Robert H Mach2.   

Abstract

Dopamine D3 receptors have key roles in behavioral reward, addiction, Parkinson's disease, and schizophrenia, and there is interest in studying their role in these disorders using PET. However, current PET radiotracers for studying D3 receptors in humans all bind to both D2 and D3 due to similarities between the two receptors. Selective D2 and D3 radioligands would aid investigation of the differences between D2 and D3 circuitry in the central nervous system. While there are currently in vitro measures of ligand D3/D2 selectivity, there is a need for an in vivo PET measure of D3/D2 selectivity. This review discusses current PET imaging of dopamine D2/D3 receptors and proposes methodology for quantitating in vivo selectivity of probes for PET imaging of dopamine D3 receptors.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  D3 receptors; Dopamine; PET radiotracers

Mesh：

Substances：

Year:  2018        PMID： 29518538      PMCID： PMC6123300          DOI： 10.1016/j.neulet.2018.03.006

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  88 in total

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10.  Levodopa effects on [ (11)C]raclopride binding in the resting human brain.

Authors:  Kevin J Black; Marilyn L Piccirillo; Jonathan M Koller; Tiffany Hseih; Lei Wang; Mark A Mintun
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