Andrew J Sinnamon1, Cimarron E Sharon2, Yun Song2, Madalyn G Neuwirth2, David E Elder3, Xiaowei Xu3, Emily Y Chu4, Michael E Ming4, Douglas L Fraker2, Phyllis A Gimotty5, Giorgos C Karakousis2. 1. Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: andrew.sinnamon@uphs.upenn.edu. 2. Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. 3. Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. 4. Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. 5. Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania.
Abstract
BACKGROUND: The immune response to melanoma is manifested locally by tumor-infiltrating lymphocytes (TILs). Men and women are known to have varying patterns of immunity, yet sex-specific prognostic implications of TILs have not been explored. METHODS: Patients who had clinically localized primary melanoma with a Breslow thickness of 0.76 mm or more and underwent sentinel lymph node (SLN) biopsy at our institution were identified. The association between TILs (absent, nonbrisk, and brisk) and SLN positivity was evaluated by using logistic regression. Overall survival (OS) was evaluated by TIL status and sex. RESULTS: Among 1367 patients identified, 794 were men. TILs were brisk in 143 lesions, nonbrisk in 903, and absent in 321, which did not vary by sex (P = .71). SLN positivity was associated with TILs among men (brisk, 3.8%; nonbrisk, 16.9%; and absent, 26.6% [P < .001]). In contrast, there was no association between SLN positivity and TILs among women (P = .49). Interaction between brisk TILs and sex on SLN positivity was significant (P = .029). Among men, presence of brisk TILs was associated with prolonged OS (P = .038) but not after adjustment for SLN status (P = .42). There was no association between TIL status and OS among women. LIMITATIONS: Findings from this single-institution study have yet to be validated by other research groups. CONCLUSIONS: The implications of TILs in predicting SLN positivity appear to be more relevant for men than for women.
BACKGROUND: The immune response to melanoma is manifested locally by tumor-infiltrating lymphocytes (TILs). Men and women are known to have varying patterns of immunity, yet sex-specific prognostic implications of TILs have not been explored. METHODS:Patients who had clinically localized primary melanoma with a Breslow thickness of 0.76 mm or more and underwent sentinel lymph node (SLN) biopsy at our institution were identified. The association between TILs (absent, nonbrisk, and brisk) and SLN positivity was evaluated by using logistic regression. Overall survival (OS) was evaluated by TIL status and sex. RESULTS: Among 1367 patients identified, 794 were men. TILs were brisk in 143 lesions, nonbrisk in 903, and absent in 321, which did not vary by sex (P = .71). SLN positivity was associated with TILs among men (brisk, 3.8%; nonbrisk, 16.9%; and absent, 26.6% [P < .001]). In contrast, there was no association between SLN positivity and TILs among women (P = .49). Interaction between brisk TILs and sex on SLN positivity was significant (P = .029). Among men, presence of brisk TILs was associated with prolonged OS (P = .038) but not after adjustment for SLN status (P = .42). There was no association between TIL status and OS among women. LIMITATIONS: Findings from this single-institution study have yet to be validated by other research groups. CONCLUSIONS: The implications of TILs in predicting SLN positivity appear to be more relevant for men than for women.
Authors: Richard J Straker; Katharine Krupp; Cimarron E Sharon; Alexandra S Thaler; Nicholas J Kelly; Emily Y Chu; David E Elder; Xiaowei Xu; John T Miura; Giorgos C Karakousis Journal: Ann Surg Oncol Date: 2022-03-17 Impact factor: 4.339
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Authors: Michael R Moore; Isabel D Friesner; Emanuelle M Rizk; Jing Wang; Rami Vanguri; Yvonne M Saenger; Benjamin T Fullerton; Manas Mondal; Megan H Trager; Karen Mendelson; Ijeuru Chikeka; Tahsin Kurc; Rajarsi Gupta; Bethany R Rohr; Eric J Robinson; Balazs Acs; Rui Chang; Harriet Kluger; Bret Taback; Larisa J Geskin; Basil Horst; Kevin Gardner; George Niedt; Julide T Celebi; Robyn D Gartrell-Corrado; Jane Messina; Tammie Ferringer; David L Rimm; Joel Saltz Journal: Sci Rep Date: 2021-02-02 Impact factor: 4.379