Tobias Luck1, Alexander Pabst2, Francisca S Rodriguez2, Matthias L Schroeter3, Veronica Witte3, Andreas Hinz4, Anja Mehnert4, Christoph Engel5, Markus Loeffler5, Joachim Thiery6, Arno Villringer3, Steffi G Riedel-Heller2. 1. University of Leipzig, Institute of Social Medicine, Occupational Health and Public Health. 2. Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig. 3. Max Planck Institute for Human Cognitive and Brain Sciences. 4. Department of Medical Psychology and Medical Sociology, University of Leipzig. 5. Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig. 6. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University Hospital Leipzig.
Abstract
OBJECTIVE: To provide new age-, sex-, and education-specific reference values for an extended version of the well-established Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NAB) that additionally includes the Trail Making Test and the Verbal Fluency Test-S-Words. METHOD: Norms were calculated based on the cognitive performances of n = 1,888 dementia-free participants (60-79 years) from the population-based German LIFE-Adult-Study. Multiple regressions were used to examine the association of the CERAD-NAB scores with age, sex, and education. In order to calculate the norms, quantile and censored quantile regression analyses were performed estimating marginal means of the test scores at 2.28, 6.68, 10, 15.87, 25, 50, 75, and 90 percentiles for age-, sex-, and education-specific subgroups. RESULTS: Multiple regression analyses revealed that younger age was significantly associated with better cognitive performance in 15 CERAD-NAB measures and higher education with better cognitive performance in all 17 measures. Women performed significantly better than men in 12 measures and men than women in four measures. The determined norms indicate ceiling effects for the cognitive performances in the Boston Naming, Word List Recognition, Constructional Praxis Copying, and Constructional Praxis Recall tests. CONCLUSIONS: The new norms for the extended CERAD-NAB will be useful for evaluating dementia-free German-speaking adults in a broad variety of relevant cognitive domains. The extended CERAD-NAB follows more closely the criteria for the new DSM-5 Mild and Major Neurocognitive Disorder. Additionally, it could be further developed to include a test for social cognition. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
OBJECTIVE: To provide new age-, sex-, and education-specific reference values for an extended version of the well-established Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NAB) that additionally includes the Trail Making Test and the Verbal Fluency Test-S-Words. METHOD: Norms were calculated based on the cognitive performances of n = 1,888 dementia-freeparticipants (60-79 years) from the population-based German LIFE-Adult-Study. Multiple regressions were used to examine the association of the CERAD-NAB scores with age, sex, and education. In order to calculate the norms, quantile and censored quantile regression analyses were performed estimating marginal means of the test scores at 2.28, 6.68, 10, 15.87, 25, 50, 75, and 90 percentiles for age-, sex-, and education-specific subgroups. RESULTS: Multiple regression analyses revealed that younger age was significantly associated with better cognitive performance in 15 CERAD-NAB measures and higher education with better cognitive performance in all 17 measures. Women performed significantly better than men in 12 measures and men than women in four measures. The determined norms indicate ceiling effects for the cognitive performances in the Boston Naming, Word List Recognition, Constructional Praxis Copying, and Constructional Praxis Recall tests. CONCLUSIONS: The new norms for the extended CERAD-NAB will be useful for evaluating dementia-free German-speaking adults in a broad variety of relevant cognitive domains. The extended CERAD-NAB follows more closely the criteria for the new DSM-5 Mild and Major Neurocognitive Disorder. Additionally, it could be further developed to include a test for social cognition. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
Authors: Maryam Yahiaoui-Doktor; Tobias Luck; Steffi G Riedel-Heller; Markus Loeffler; Kerstin Wirkner; Christoph Engel Journal: Alzheimers Res Ther Date: 2019-05-10 Impact factor: 6.982
Authors: Annika Kreuzer; Julia Sauerbeck; Maximilian Scheifele; Anna Stockbauer; Sonja Schönecker; Catharina Prix; Elisabeth Wlasich; Sandra V Loosli; Philipp M Kazmierczak; Marcus Unterrainer; Cihan Catak; Daniel Janowitz; Oliver Pogarell; Carla Palleis; Robert Perneczky; Nathalie L Albert; Peter Bartenstein; Adrian Danek; Katharina Buerger; Johannes Levin; Andreas Zwergal; Axel Rominger; Matthias Brendel; Leonie Beyer Journal: Front Aging Neurosci Date: 2021-02-02 Impact factor: 5.750
Authors: Johanna Girbardt; Tobias Luck; Jana Kynast; Francisca S Rodriguez; Barbara Wicklein; Kerstin Wirkner; Christoph Engel; Christian Girbardt; Mengyu Wang; Maryna Polyakova; A Veronica Witte; Markus Loeffler; Arno Villringer; Steffi G Riedel-Heller; Matthias L Schroeter; Tobias Elze; Franziska G Rauscher Journal: Brain Commun Date: 2021-11-08