Dilek Ceylan1, Ahmet Aksoy2, Tolga Ertekin3, Arzu Hanım Yay4, Mehtap Nisari3, Gökçe Şeker Karatoprak5, Harun Ülger3. 1. Genome and Stem Cell Center, University of Erciyes, Kayseri, Turkey. 2. Department of Biology, School of Arts and Sciences, University of Akdeniz, Antalya, Turkey. 3. Department of Anatomy, School of Medicine, University of Erciyes, Kayseri, Turkey. 4. Department of Histology and Embryology, School of Medicine, University of Erciyes, Kayseri, Turkey. 5. Department of Pharmacognosis, School of Pharmacy, University of Erciyes, Kayseri, Turkey.
Abstract
OBJECTIVE: The aim of study was to investigate anticancer effect of Viburnum opulus (VO) on Ehrlich ascites carcinoma (EAC) bearing mice that treated with different concentrations of VO. MATERIALS AND METHODS: For tumor transplantation; mice were inoculated with 1 × 106 EAC cells intraperitoneally and than divided into five groups (n = 9). Two hours after inoculation; experimental groups were treated daily with VO extract at doses of 1000 mg/kg, 2000 mg/kg, 4000 mg/kg. RESULTS: Extracts obtained from gilaburu juice can have hinder effect on tumor cell growth. CONCLUSION: As far as we known, this is the first study about in vivo antitumoral activity of VOon Ehrlich ascites tumor model, and consequently VO extract exhibited anticancer activity against EAC-bearing mice.
OBJECTIVE: The aim of study was to investigate anticancer effect of Viburnum opulus (VO) on Ehrlich ascites carcinoma (EAC) bearing mice that treated with different concentrations of VO. MATERIALS AND METHODS: For tumor transplantation; mice were inoculated with 1 × 106 EAC cells intraperitoneally and than divided into five groups (n = 9). Two hours after inoculation; experimental groups were treated daily with VO extract at doses of 1000 mg/kg, 2000 mg/kg, 4000 mg/kg. RESULTS: Extracts obtained from gilaburu juice can have hinder effect on tumor cell growth. CONCLUSION: As far as we known, this is the first study about in vivo antitumoral activity of VOon Ehrlich ascites tumor model, and consequently VO extract exhibited anticancer activity against EAC-bearing mice.