| Literature DB >> 29516402 |
Gergely Bodis1,2, Victoria Toth1,2, Andreas Schwarting3,4.
Abstract
Since the discovery of HLA 60 years ago, it has contributed to the understanding of the immune system as well as of the pathogenesis of several diseases. Aside from its essential role in determining donor-recipient immune compatibility in organ transplantation, HLA genotyping is meanwhile performed routinely as part of the diagnostic work-up of certain autoimmune diseases. Considering the ability of HLA to influence thymic selection as well as peripheral anergy of T cells, its role in the pathogenesis of autoimmunity is understandable. The aim of this paper is to provide a brief overview of the role and current clinical relevance of HLA-B27 in spondyloarthritis and HLA-B51 in Behçet's disease as well as HLA-DQ2/DQ8 in celiac disease and HLA-DRB1 in rheumatoid arthritis and to discuss possible future implications.Entities:
Keywords: Autoimmunity; Behçet's disease; Celiac disease; Genotyping; Human leucocyte antigen; MHC class I; MHC class II; Rheumatoid arthritis; Shared epitopes; Spondylarthritis
Year: 2018 PMID： 29516402 PMCID： PMC5935613 DOI： 10.1007/s40744-018-0100-z
Source DB: PubMed Journal: Rheumatol Ther ISSN： 2198-6576