Literature DB >> 2951595

Deficient function of the sarcoplasmic reticulum in patients susceptible to malignant hyperthermia.

M Condrescu, J R López, P Medina, L Alamo.   

Abstract

Calcium uptake and (Ca2+ + Mg2+)-ATPase were measured in sarcoplasmic reticulum (SR) vesicles prepared from muscles of eight patients susceptible to malignant hyperthermia (MH) and eight control subjects. Intracellular resting free calcium level of some of the studied subjects was also determined. Both calcium uptake capacity and (Ca2+ + Mg2+)-ATPase activity were significantly lower in SR prepared from MH-susceptible patients than from normal subjects. Besides, in these MH-susceptible patients myoplasmic free Ca2+ was increased. These results corroborate previous suggestions that abnormal function of the SR membrane was related to the MH syndrome.

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Year:  1987        PMID： 2951595     DOI： 10.1002/mus.880100307

Source DB:  PubMed          Journal:  Muscle Nerve        ISSN： 0148-639X            Impact factor:   3.217


  2 in total

1.  Chronic Elevation of Skeletal Muscle [Ca2+]i Impairs Glucose Uptake. An in Vivo and in Vitro Study.

Authors:  Arkady Uryash; Alfredo Mijares; Carlos E Lopez; Jose A Adams; Jose R Lopez
Journal:  Front Physiol       Date:  2022-04-25       Impact factor: 4.755

2.  Inhibition of sarcoplasmic Ca2+-ATPase increases caffeine- and halothane-induced contractures in muscle bundles of malignant hyperthermia susceptible and healthy individuals.

Authors:  Frank Schuster; Rainer Müller; Edmund Hartung; Norbert Roewer; Martin Anetseder
Journal:  BMC Anesthesiol       Date:  2005-06-09       Impact factor: 2.217
  2 in total

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