Francisco-Javier Gonzalez-Barcala1, Maria-Esther San-Jose2, Juan-José Nieto-Fontarigo3, Jose-Martín Carreira4, Uxio Calvo-Alvarez5, Maria-Jesus Cruz6, David Facal7, Maria-Teresa Garcia-Sanz8, Luis Valdes-Cuadrado9, Francisco-Javier Salgado3. 1. Department of Medicine-University of Santiago de Compostela, Spain; Spanish Biomedical Research Networking Centre-CIBERES, Spain; Department of Respiratory Medicine-University Hospital of Santiago de Compostela, Spain; Health Research Institute of Santiago de Compostela (IDIS), Spain. Electronic address: Francisco.javier.gonzalez.barcala@sergas.es. 2. Clinical Analysis Service, University Hospital of Santiago de Compostela (CHUS), Spain. 3. Department of Biochemistry and Molecular Biology, Faculty of Biology-Biological Research Centre (CIBUS), Universidade de Santiago de Compostela, Spain. 4. Department of Radiology-University of Santiago de Compostela, Spain. 5. Department of Respiratory Medicine-University Hospital of El Ferrol, Spain. 6. Spanish Biomedical Research Networking Centre-CIBERES, Spain; Department of Respiratory Medicine-Hospital Vall d'Hebron, Spain. 7. Spanish Biomedical Research Networking Centre-CIBERES, Spain; Department of Developmental Psychology, University of Santiago de Compostela, Spain. 8. Emergency Department-Hospital O Salnes, Spain. 9. Department of Medicine-University of Santiago de Compostela, Spain; Department of Respiratory Medicine-University Hospital of Santiago de Compostela, Spain; Health Research Institute of Santiago de Compostela (IDIS), Spain.
Abstract
INTRODUCTION: The presence of eosinophils in asthma inflammation is a relevant factor in the pathophysiology of the disease, however the relationship between the blood eosinophil count (BEC) with asthma severity and prognosis is still under debate. The aim of this work is to analyze the relationship between the BEC levels and hospital readmissions in patients with asthma. MATERIAL AND METHODS: A review was retrospectively carried out on all admissions of patients over 18 years old due to exacerbation of asthma occurring in our hospital between the years 2000 and 2010. The personal characteristics and the asthma personal history of each patient were recorded. The BEC was determined from the first blood sample taken from the patient after their arrival at the hospital. Hospital early, late and frequent readmissions were analyzed using 4 cut-off points; less than 150 eosinophils/μL vs ≥150/μL, less than 200 vs 200 /μL, less than 300 vs ≥300/μL, and less than 400 vs ≥400/μL. RESULTS: We have included 1316 patients, 70% of whom are women, as well as a mean age of 60 years, and a mean FEV1 of 73.5% of the reference value. The mean eosinophil blood count was 201.7 cells/μL. A BEC ≥300 cells/μL showed a reduction of risk of late readmission of 42%, a BEC ≥400 cells/μL showed a reduction in late readmission risk of 41% and decrease in frequent late readmission of 63%. CONCLUSIONS: Our study appears to support that an elevated BEC is associated with a lower incidence of asthma hospital readmissions.
INTRODUCTION: The presence of eosinophils in asthma inflammation is a relevant factor in the pathophysiology of the disease, however the relationship between the blood eosinophil count (BEC) with asthma severity and prognosis is still under debate. The aim of this work is to analyze the relationship between the BEC levels and hospital readmissions in patients with asthma. MATERIAL AND METHODS: A review was retrospectively carried out on all admissions of patients over 18 years old due to exacerbation of asthma occurring in our hospital between the years 2000 and 2010. The personal characteristics and the asthma personal history of each patient were recorded. The BEC was determined from the first blood sample taken from the patient after their arrival at the hospital. Hospital early, late and frequent readmissions were analyzed using 4 cut-off points; less than 150 eosinophils/μL vs ≥150/μL, less than 200 vs 200 /μL, less than 300 vs ≥300/μL, and less than 400 vs ≥400/μL. RESULTS: We have included 1316 patients, 70% of whom are women, as well as a mean age of 60 years, and a mean FEV1 of 73.5% of the reference value. The mean eosinophil blood count was 201.7 cells/μL. A BEC ≥300 cells/μL showed a reduction of risk of late readmission of 42%, a BEC ≥400 cells/μL showed a reduction in late readmission risk of 41% and decrease in frequent late readmission of 63%. CONCLUSIONS: Our study appears to support that an elevated BEC is associated with a lower incidence of asthma hospital readmissions.
Authors: K E J Håkansson; Line J H Rasmussen; Nina S Godtfredsen; Oliver D Tupper; Jesper Eugen-Olsen; Thomas Kallemose; Ove Andersen; Charlotte Suppli Ulrik Journal: Respir Res Date: 2019-11-15
Authors: Marjan Kerkhof; Trung N Tran; Maarten van den Berge; Guy G Brusselle; Gokul Gopalan; Rupert C M Jones; Janwillem W H Kocks; Andrew Menzies-Gow; Javier Nuevo; Ian D Pavord; Sarang Rastogi; David B Price Journal: PLoS One Date: 2018-07-25 Impact factor: 3.240