| Literature DB >> 29514068 |
Kevin M Tharp1, Michael S Kang2, Greg A Timblin3, Jon Dempersmier4, Garret E Dempsey4, Peter-James H Zushin4, Jaime Benavides4, Catherine Choi4, Catherine X Li4, Amit K Jha5, Shingo Kajimura6, Kevin E Healy7, Hei Sook Sul4, Kaoru Saijo3, Sanjay Kumar8, Andreas Stahl9.
Abstract
The activation of brown/beige adipose tissue (BAT) metabolism and the induction of uncoupling protein 1 (UCP1) expression are essential for BAT-based strategies to improve metabolic homeostasis. Here, we demonstrate that BAT utilizes actomyosin machinery to generate tensional responses following adrenergic stimulation, similar to muscle tissues. The activation of actomyosin mechanics is critical for the acute induction of oxidative metabolism and uncoupled respiration in UCP1+ adipocytes. Moreover, we show that actomyosin-mediated elasticity regulates the thermogenic capacity of adipocytes via the mechanosensitive transcriptional co-activators YAP and TAZ, which are indispensable for normal BAT function. These biomechanical signaling mechanisms may inform future strategies to promote the expansion and activation of brown/beige adipocytes.Entities:
Keywords: UCP1; YAP/TAZ; actomyosin; beige adipose; brown adipose; mechanobiology; metabolism; oxidative metabolism; thermogenesis; uncoupled respiration
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Year: 2018 PMID： 29514068 PMCID： PMC5897043 DOI： 10.1016/j.cmet.2018.02.005
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287