| Literature DB >> 29514056 |
Dongdong Wu1, Honggang Wang1, Tieshan Teng1, Shaofeng Duan2, Ailing Ji3, Yanzhang Li4.
Abstract
Hydrogen sulfide (H2S) has been considered the third gaseous signaling molecule that plays important roles in a wide range of physiological and pathological conditions. However, there has been some controversy on the role of H2S in autophagy. Recent studies indicate that a number of signaling pathways are involved in the pro-autophagy effect of H2S, such as PI3K/Akt/mTOR, AMPK/mTOR, LKB1/STRAD/MO25, and miR-30c signaling pathways. On the other hand, there are many signaling pathways that play important roles in the anti-autophagy effect of H2S, including SR-A, PI3K/SGK1/GSK3β, PI3K/AKT/mTOR, Nrf2-ROS-AMPK, AMPK/mTOR, and JNK1 signaling pathways. Novel H2S-releasing donors/drugs could be designed and identified in order to increase the therapeutic effects by mediating autophagy in human diseases. In this review, the H2S metabolism in mammals is summarized and the effects of signaling pathways in H2S-mediated autophagy are further discussed.Entities:
Keywords: AMPK; Autophagy; Human diseases; Hydrogen sulfide; Metabolism; mTOR
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Year: 2018 PMID： 29514056 DOI： 10.1016/j.phrs.2018.03.002
Source DB: PubMed Journal: Pharmacol Res ISSN： 1043-6618 Impact factor: 7.658