Luciano Pamplona de Góes Cavalcanti1, Sara Mendes D'angelo1, Daniele Rocha Queiroz Lemos2, Francisca Kalline de Almeida Barreto1, André Machado Siqueira3, Fabio Miyajima4,5. 1. Programa de Pós-Graduação em Saúde Pública, Universidade Federal do Ceará, Fortaleza, CE, Brasil. 2. Centro Universitário Christus, Fortaleza, CE, Brasil. 3. Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil. 4. Centro de Pesquisas e Desenvolvimento de Medicamentos, Universidade Federal do Ceará, Fortaleza, CE, Brasil. 5. Institute of Translational Medicine, University of Liverpool. Liverpool, United Kingdom.
Abstract
INTRODUCTION: Chikungunya virus (CHIKV) can negatively influence outcomes in patients with pre-existing conditions. We investigated the association between the recent CHIKV outbreak and increased type 2 diabetes (T2D)-attributable deaths. METHODS: Monthly averages of T2D-attributable deaths between 2001 and 2016 were determined and compared to the equivalent data for 2017 and the recent CHIKV outbreak. RESULTS: CHKV outbreak peaked in April 2017 with 4,394.4 cases/100,000 inhabitants, while T2D-attributable deaths in the same period increased by 35.2%. CONCLUSIONS: T2D-attributable deaths significantly increased compared to the previous data, which overlapped with CHIKV incidence. The pathophysiology of this association warrants further investigations.
INTRODUCTION:Chikungunya virus (CHIKV) can negatively influence outcomes in patients with pre-existing conditions. We investigated the association between the recent CHIKV outbreak and increased type 2 diabetes (T2D)-attributable deaths. METHODS: Monthly averages of T2D-attributable deaths between 2001 and 2016 were determined and compared to the equivalent data for 2017 and the recent CHIKV outbreak. RESULTS: CHKV outbreak peaked in April 2017 with 4,394.4 cases/100,000 inhabitants, while T2D-attributable deaths in the same period increased by 35.2%. CONCLUSIONS: T2D-attributable deaths significantly increased compared to the previous data, which overlapped with CHIKV incidence. The pathophysiology of this association warrants further investigations.
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