Literature DB >> 29513321

Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways.

Hitomi Nakamura1, Yudai Matsuda, Ikuro Abe.   

Abstract

Covering: up to 2018 Non-heme iron enzymes are a versatile family of oxygenases that catalyze remarkable types of chemistry. This review highlights the intriguing chemistry of non-heme iron enzymes, especially those utilizing α-ketoglutarate (α-KG) as a co-substrate, in fungal secondary metabolism and aims to summarize how nature diversifies and complexifies natural products.

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Year:  2018        PMID： 29513321     DOI： 10.1039/c7np00055c

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  14 in total

Review 1.  Enzymatic Cascade Reactions in Biosynthesis.

Authors:  Christopher T Walsh; Bradley S Moore
Journal:  Angew Chem Int Ed Engl       Date:  2019-02-20       Impact factor: 15.336

2.  Chemoenzymatic o-Quinone Methide Formation.

Authors:  Tyler J Doyon; Jonathan C Perkins; Summer A Baker Dockrey; Evan O Romero; Kevin C Skinner; Paul M Zimmerman; Alison R H Narayan
Journal:  J Am Chem Soc       Date:  2019-12-16       Impact factor: 15.419

3.  Engineered and Artificial Metalloenzymes for Selective C-H Functionalization.

Authors:  Xinkun Ren; Rudi Fasan
Journal:  Curr Opin Green Sustain Chem       Date:  2021-04-08

4.  Mechanism of Methyldehydrofosmidomycin Maturation: Use Olefination to Enable Chain Elongation.

Authors:  Xiaojun Li; Shan Xue; Yisong Guo; Wei-Chen Chang
Journal:  J Am Chem Soc       Date:  2022-04-28       Impact factor: 16.383

Review 5.  Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses.

Authors:  Shu-Shan Gao; Nathchar Naowarojna; Ronghai Cheng; Xueting Liu; Pinghua Liu
Journal:  Nat Prod Rep       Date:  2018-08-15       Impact factor: 13.423

6.  Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI.

Authors:  Takahiro Mori; Rui Zhai; Richiro Ushimaru; Yudai Matsuda; Ikuro Abe
Journal:  Nat Commun       Date:  2021-07-20       Impact factor: 14.919

Review 7.  Harnessing ortho-Quinone Methides in Natural Product Biosynthesis and Biocatalysis.

Authors:  Trevor N Purdy; Bradley S Moore; April L Lukowski
Journal:  J Nat Prod       Date:  2022-02-02       Impact factor: 4.803

8.  Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor.

Authors:  Huaqiang Li; Weiguang Sun; Mengyi Deng; Changxing Qi; Chunmei Chen; Hucheng Zhu; Zengwei Luo; Jianping Wang; Yongbo Xue; Yonghui Zhang
Journal:  Mar Drugs       Date:  2018-05-23       Impact factor: 5.118

9.  Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids.

Authors:  Takaaki Mitsuhashi; Lena Barra; Zachary Powers; Volga Kojasoy; Andrea Cheng; Feng Yang; Yoshimasa Taniguchi; Takashi Kikuchi; Makoto Fujita; Dean J Tantillo; John A Porco; Ikuro Abe
Journal:  Angew Chem Int Ed Engl       Date:  2020-10-22       Impact factor: 15.336

10.  Structural basis for divergent C-H hydroxylation selectivity in two Rieske oxygenases.

Authors:  April L Lukowski; Jianxin Liu; Jennifer Bridwell-Rabb; Alison R H Narayan
Journal:  Nat Commun       Date:  2020-06-12       Impact factor: 14.919
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