| Literature DB >> 29512930 |
Galen M Kabulski1,2, Shawn H MacVane1,3.
Abstract
Previous studies of patients with cystic fibrosis (CF) treated with azole antifungals have shown altered pharmacokinetics relative to healthy patients. Data regarding the pharmacokinetic profile of isavuconazole in patients with CF undergoing lung transplantation are currently not available. Serum trough concentrations assessed in a single CF patient following transplant revealed significantly lower values relative to available literature. Larger studies are required to validate CF population pharmacokinetics of isavuconazole.Entities:
Keywords: cystic fibrosis; isavuconazole; lung transplant; mucormycosis; pharmacokinetics
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Year: 2018 PMID： 29512930 DOI： 10.1111/tid.12878
Source DB: PubMed Journal: Transpl Infect Dis ISSN： 1398-2273 Impact factor: 2.228