Paraskevi Xepapadaki1, Claus Bachert2, Susetta Finotto3, Tuomas Jartti4, George N Konstantinou5, Alexander Kiefer6, Marek Kowalski7, Anna Lewandowska-Polak7,8, Heikki Lukkarinen4, Eirini Roumpedaki1, Anna Sobanska7, Ina Sintobin2, Tytti Vuorinen9, Nan Zhang2, Theodor Zimmermann6, Nikolaos G Papadopoulos1,10. 1. Allergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece. 2. Upper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium. 3. Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany. 4. Department of Pediatrics, Turku University Hospital and University of Turku, Turku, Finland. 5. Department of Allergy and Clinical Immunology, 424 General Military Training Hospital, Thessaloniki, Greece. 6. Department of Pediatrics and Adolescent Medicine, Department of Allergy and Pneumology, Children's Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany. 7. Department of Immunology, Rheumatology and Allergy, Central University Hospital, Lodz, Poland. 8. Department of Rheumatology, Medical University of Lodz, Lodz, Poland. 9. Department of Clinical Virology, Turku University Hospital, Department of Virology, Turku University, Turku, Finland. 10. Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, UK.
Abstract
BACKGROUND: The PreDicta cohort was designed to prospectively evaluate wheeze/asthma persistence in preschoolers in association with viral/microbial exposures and immunological responses. We present the cohort design and demographic/disease characteristics and evaluate unsupervised and predefined phenotypic subgroups at inclusion. METHODS: PreDicta is a 2-year prospective study conducted in five European regions, including children 4-6 years with a diagnosis of asthma as cases and healthy age-matched controls. At baseline, detailed information on demographics, asthma and allergy-related disease activity, exposures, and lifestyle were recorded. Lung function, airway inflammation, and immune responses were also assessed. Power analysis confirmed that the cohort is adequate to answer the initial hypothesis. RESULTS: A total of 167 asthmatic children (102 males) and 66 healthy controls (30 males) were included. Groups were homogeneous in respect to most baseline characteristics, with the exception of male gender in cases (61%) and exposure to tobacco smoke. Comorbidities and number and duration of infections were significantly higher in asthmatics than controls. 55.7% of asthmatic children had at least one positive skin prick test to aeroallergens (controls: 33.3%, P = .002). Spirometric and exhaled nitric oxide values were within normal limits; only baseline FEV0.5 and FEV1 reversibility values were significantly different between groups. Viral infections were the most common triggers (89.2%) independent of severity, control, or atopy; however, overlapping phenotypes were also common. Severity and control clustered together in an unsupervised analysis, separating moderate from mild disease. CONCLUSIONS: The PreDicta cohort presented no differences in non-asthma related measures; however, it is well balanced regarding key phenotypic characteristics representative of "preschool asthma".
BACKGROUND: The PreDicta cohort was designed to prospectively evaluate wheeze/asthma persistence in preschoolers in association with viral/microbial exposures and immunological responses. We present the cohort design and demographic/disease characteristics and evaluate unsupervised and predefined phenotypic subgroups at inclusion. METHODS: PreDicta is a 2-year prospective study conducted in five European regions, including children 4-6 years with a diagnosis of asthma as cases and healthy age-matched controls. At baseline, detailed information on demographics, asthma and allergy-related disease activity, exposures, and lifestyle were recorded. Lung function, airway inflammation, and immune responses were also assessed. Power analysis confirmed that the cohort is adequate to answer the initial hypothesis. RESULTS: A total of 167 asthmatic children (102 males) and 66 healthy controls (30 males) were included. Groups were homogeneous in respect to most baseline characteristics, with the exception of male gender in cases (61%) and exposure to tobacco smoke. Comorbidities and number and duration of infections were significantly higher in asthmatics than controls. 55.7% of asthmatic children had at least one positive skin prick test to aeroallergens (controls: 33.3%, P = .002). Spirometric and exhaled nitric oxide values were within normal limits; only baseline FEV0.5 and FEV1 reversibility values were significantly different between groups. Viral infections were the most common triggers (89.2%) independent of severity, control, or atopy; however, overlapping phenotypes were also common. Severity and control clustered together in an unsupervised analysis, separating moderate from mild disease. CONCLUSIONS: The PreDicta cohort presented no differences in non-asthma related measures; however, it is well balanced regarding key phenotypic characteristics representative of "preschool asthma".
Authors: Spyridon Megremis; Katarzyna Niespodziana; Clarissa Cabauatan; Paraskevi Xepapadaki; Marek L Kowalski; Tuomas Jartti; Claus Bachert; Susetta Finotto; Peter West; Sofia Stamataki; Anna Lewandowska-Polak; Heikki Lukkarinen; Nan Zhang; Theodor Zimmermann; Frank Stolz; Angela Neubauer; Mübeccel Akdis; Evangelos Andreakos; Rudolf Valenta; Nikolaos G Papadopoulos Journal: Am J Respir Crit Care Med Date: 2018-12-15 Impact factor: 21.405
Authors: Debbie J Maurer; Chengyao Liu; Paraskevi Xepapadaki; Barbara Stanic; Claus Bachert; Susetta Finotto; Ya-Dong Gao; Anna Graser; Tuomas Jartti; Walter Kistler; Marek Kowalski; Heikki Lukkarinen; Maria Pasioti; Ge Tan; Michael Villiger; Luo Zhang; Nan Zhang; Mübeccel Akdis; Nikolaos G Papadopoulos; Cezmi A Akdis Journal: Allergy Date: 2021-10-04 Impact factor: 14.710
Authors: Paraskevi Xepapadaki; Paraskevi Korovessi; Claus Bachert; Susetta Finotto; Tuomas Jartti; John Lakoumentas; Marek L Kowalski; Anna Lewandowska-Polak; Heikki Lukkarinen; Nan Zhang; Theodor Zimmermann; Nikolaos G Papadopoulos Journal: J Clin Med Date: 2020-01-09 Impact factor: 4.241
Authors: Tuomas Jartti; Unna Liimatainen; Paraskevi Xepapadaki; Tero Vahlberg; Claus Bachert; Susetta Finotto; Marek L Kowalski; Anna Sobanska; Heikki Lukkarinen; Maria Pasioti; Tytti Vuorinen; Nan Zhang; Theodor Zimmermann; Nikolaos G Papadopoulos Journal: Allergy Date: 2020-07-21 Impact factor: 13.146
Authors: Katarzyna Niespodziana; Katarina Stenberg-Hammar; Nikolaos G Papadopoulos; Margarete Focke-Tejkl; Peter Errhalt; Jon R Konradsen; Cilla Söderhäll; Marianne van Hage; Gunilla Hedlin; Rudolf Valenta Journal: Viruses Date: 2021-05-15 Impact factor: 5.048
Authors: George N Konstantinou; Nikolaos G Papadopoulos; Emmanouel Manousakis; Paraskevi Xepapadaki Journal: J Clin Med Date: 2019-09-16 Impact factor: 4.241
Authors: Katarzyna Niespodziana; Kristina Borochova; Petra Pazderova; Thomas Schlederer; Natalia Astafyeva; Tatiana Baranovskaya; Mohamed-Ridha Barbouche; Evgeny Beltyukov; Angelika Berger; Elena Borzova; Jean Bousquet; Roxana S Bumbacea; Snezhana Bychkovskaya; Luis Caraballo; Kian Fan Chung; Adnan Custovic; Guillermo Docena; Thomas Eiwegger; Irina Evsegneeva; Alexander Emelyanov; Peter Errhalt; Rustem Fassakhov; Rezeda Fayzullina; Elena Fedenko; Daria Fomina; Zhongshan Gao; Pedro Giavina-Bianchi; Maia Gotua; Susanne Greber-Platzer; Gunilla Hedlin; Natalia Ilina; Zhanat Ispayeva; Marco Idzko; Sebastian L Johnston; Ömer Kalayci; Alexander Karaulov; Antonina Karsonova; Musa Khaitov; Elena Kovzel; Marek L Kowalski; Dmitry Kudlay; Michael Levin; Svetlana Makarova; Paolo Maria Matricardi; Kari C Nadeau; Leyla Namazova-Baranova; Olga Naumova; Oleksandr Nazarenko; Paul M O'Byrne; Faith Osier; Alexander N Pampura; Carmen Panaitescu; Nikolaos G Papadopoulos; Hae-Sim Park; Ruby Pawankar; Wolfgang Pohl; Harald Renz; Ksenja Riabova; Vanitha Sampath; Bülent E Sekerel; Elopy Sibanda; Valérie Siroux; Ludmila P Sizyakina; Jin-Lyu Sun; Zsolt Szepfalusi; Tetiana Umanets; Hugo P S Van Bever; Marianne van Hage; Margarita Vasileva; Erika von Mutius; Jiu-Yao Wang; Gary W K Wong; Sergii Zaikov; Mihaela Zidarn; Rudolf Valenta Journal: J Allergy Clin Immunol Date: 2020-02-18 Impact factor: 14.290