James T Thackeray1. 1. Department of Nuclear Medicine, Hannover Medical School, Carl Neuberg-Str. 1, 30625, Hannover, Germany. Thackeray.James@mh-hannover.de.
Abstract
PURPOSE OF REVIEW: Local inflammation after myocardial infarction (MI) plays a role in subsequent ventricular remodeling, influences cardiac outcome, and has emerged as a therapeutic target. Preclinical and clinical PET imaging studies have employed a variety of radiotracers to target inflammatory leukocytes in the early stages after MI. RECENT FINDINGS: Imaging of enhanced metabolism in activated macrophages with 18F-FDG is feasible and has been associated with cardiac outcome in a small prospective study. Novel targeted PET agents show higher specificity for inflammatory leukocytes and can identify therapeutic response with limited background. While PET imaging of acute inflammation after MI has grown in recent years, significant challenges remain to widespread clinical application, including the complex cellular composition of the imaging signal and unclear association with functional outcome. Future studies must address the prognostic value of post-MI inflammation imaging and the ability to discern response to targeted, expensive, and personalized therapies.
PURPOSE OF REVIEW: Local inflammation after myocardial infarction (MI) plays a role in subsequent ventricular remodeling, influences cardiac outcome, and has emerged as a therapeutic target. Preclinical and clinical PET imaging studies have employed a variety of radiotracers to target inflammatory leukocytes in the early stages after MI. RECENT FINDINGS: Imaging of enhanced metabolism in activated macrophages with 18F-FDG is feasible and has been associated with cardiac outcome in a small prospective study. Novel targeted PET agents show higher specificity for inflammatory leukocytes and can identify therapeutic response with limited background. While PET imaging of acute inflammation after MI has grown in recent years, significant challenges remain to widespread clinical application, including the complex cellular composition of the imaging signal and unclear association with functional outcome. Future studies must address the prognostic value of post-MI inflammation imaging and the ability to discern response to targeted, expensive, and personalized therapies.
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