Azadeh Montazeri 1 , Zohreh Zal 1 , Arash Ghasemi 2 , Hooman Yazdannejat 1 , Hossein Asgarian-Omran 3,4 , Seyed Jalal Hosseinimehr 1 Show Affiliations »
Abstract
BACKGROUND: Radiotherapy is an important protocol in the treatment of cancers, but radioresistance of cancerous cells is a challenge in cancer treatment. OBJECTIVE: The aim of this study was to evaluate the radiosensitizing effect of Cerium oxide Nanoparticles (CNPs) on human promyelocytic leukemia cells (HL-60). METHOD: HL-60 cells were treated with CNPs at different concentrations (10-100 μg/ml) and exposed to Ionizing Radiation (IR). The genotoxicity effects of CNPs or/and IR were assessed by micronuclei assay in HL-60 cells. RESULTS: It was found that CNPs increased the frequencies of micronuclei in HL-60 cells. CNPs pretreatment to irradiation significantly increased the IR-induced micronuclei incidences in HL-60 cells. The present study demonstrates CNPs to be an effective sensitizer on DNA damage induced by IR in HL-60 cells. CONCLUSION: These findings suggest the potential application of CNPs as a highly effective radiosensitizer for the treatment of leukemia. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Radiotherapy is an important protocol in the treatment of cancers , but radioresistance of cancerous cells is a challenge in cancer treatment. OBJECTIVE: The aim of this study was to evaluate the radiosensitizing effect of Cerium oxide Nanoparticles (CNPs) on human promyelocytic leukemia cells (HL-60). METHOD: HL-60 cells were treated with CNPs at different concentrations (10-100 μg/ml) and exposed to Ionizing Radiation (IR). The genotoxicity effects of CNPs or/and IR were assessed by micronuclei assay in HL-60 cells. RESULTS: It was found that CNPs increased the frequencies of micronuclei in HL-60 cells. CNPs pretreatment to irradiation significantly increased the IR-induced micronuclei incidences in HL-60 cells. The present study demonstrates CNPs to be an effective sensitizer on DNA damage induced by IR in HL-60 cells. CONCLUSION: These findings suggest the potential application of CNPs as a highly effective radiosensitizer for the treatment of leukemia . Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Chemical
Disease
Species
Keywords:
Cerium oxide nanoparticle; ionizing radiation; leukemia; nanoceria; radioresistance; radiosensitizing.
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Year: 2018
PMID： 29510658 DOI： 10.2174/2211738506666180306161253
Source DB: PubMed Journal: Pharm Nanotechnol ISSN： 2211-7385