The beta-endorphin response to stress during postnatal development in the rat.

The plasma beta-endorphin and adrenocortical responses to ether and handling stress were examined in animals of various ages. At each age studied there was a significant, stress-induced elevation of plasma beta-endorphin-like immunoreactivity levels. Moreover, basal beta-endorphin-like immunoreactivity levels were higher in animals 3, 7, and 14 days of age than in adults. In contrast, plasma corticosterone levels in the Day 7 pups were not elevated by stress; a finding consistent with several previous reports on the absence of increased release of adrenocorticotropin and corticosterone during stress in the neonate. These data suggest that the release of adrenocorticotropin and beta-endorphin in response to stress differ in the developing animal.