Rashmi Shingde1, L Ines Habachou1, Vaishnavi Calisa1, Jonathan C Craig1,2, Allison Tong1,2, Sharon C-A Chen3, Germaine Wong1,2,4. 1. Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, NSW, Australia. 2. Sydney School of Public Health, The University of Sydney, Sydney, NSW, Australia. 3. Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital, Sydney, NSW, Australia. 4. Centre for Transplant and Renal Research, Westmead Hospital, Sydney, NSW, Australia.
Abstract
BACKGROUND: Unexpected donor-derived transmission of infections is rare, but is associated with significant morbidity and mortality. We aimed to provide an overview of published cases on unexpected infectious transmissions. METHODS: We systematically reviewed all published evidence describing any unexpected donor-derived viral, bacterial, fungal, and parasitic infections in kidney transplant recipients. RESULTS: In all, 119 studies (case reports [n = 36], case series [n = 78], cohort studies [n = 2], and case-control studies [n = 3]) involving 139 donors and 207 kidney recipients were included. Donor-derived viral (n = 116, 56.0%) infections were most prevalent, followed by bacterial (32, 15.5%), fungal (32, 15.5%), and parasitic (27, 13.0%) infections. The most commonly reported viral infections were human immunodeficiency virus (HIV) (n = 20, 9.7%), human T-cell lymphotrophic virus (HTLV) (n = 20, 9.7%), and West Nile virus (WNV) (n = 13, 6.3%). The most frequent bacterial infections were caused by Mycobacterium tuberculosis (10, 4.8%) and Pseudomonas aeruginosa (9, 4.3%). Candida species were the most frequent causes of fungal donor-derived infections (8, 3.9%). Toxoplasma gondii accounted for seven (3.4%) cases of transmitted parasitic infections. Patients with rabies experienced the highest probability of recipient death from virus-related complications at 90.0%, within a median time of 2.8 months after transplantation. CONCLUSION: The frequency of donor-derived infectious transmission appears low in kidney transplantation, with viral transmissions being most commonly reported overall.
BACKGROUND: Unexpected donor-derived transmission of infections is rare, but is associated with significant morbidity and mortality. We aimed to provide an overview of published cases on unexpected infectious transmissions. METHODS: We systematically reviewed all published evidence describing any unexpected donor-derived viral, bacterial, fungal, and parasitic infections in kidney transplant recipients. RESULTS: In all, 119 studies (case reports [n = 36], case series [n = 78], cohort studies [n = 2], and case-control studies [n = 3]) involving 139 donors and 207 kidney recipients were included. Donor-derived viral (n = 116, 56.0%) infections were most prevalent, followed by bacterial (32, 15.5%), fungal (32, 15.5%), and parasitic (27, 13.0%) infections. The most commonly reported viral infections were human immunodeficiency virus (HIV) (n = 20, 9.7%), human T-cell lymphotrophic virus (HTLV) (n = 20, 9.7%), and West Nile virus (WNV) (n = 13, 6.3%). The most frequent bacterial infections were caused by Mycobacterium tuberculosis (10, 4.8%) and Pseudomonas aeruginosa (9, 4.3%). Candida species were the most frequent causes of fungal donor-derived infections (8, 3.9%). Toxoplasma gondii accounted for seven (3.4%) cases of transmitted parasitic infections. Patients with rabies experienced the highest probability of recipient death from virus-related complications at 90.0%, within a median time of 2.8 months after transplantation. CONCLUSION: The frequency of donor-derived infectious transmission appears low in kidney transplantation, with viral transmissions being most commonly reported overall.
Authors: Samuel Chan; Nicole M Isbel; Carmel M Hawley; Scott B Campbell; Katrina L Campbell; Mark Morrison; Ross S Francis; E Geoffrey Playford; David W Johnson Journal: Medicina (Kaunas) Date: 2019-10-04 Impact factor: 2.430
Authors: Lúcio R Requião-Moura; Elizabeth De Francesco Daher; Cassio R Moreira Albino; Savio de Oliveira Brilhante; Geraldo Bezerra da Silva Junior; Silvana Daher Costa; Tainá Veras de Sandes-Freitas Journal: Am J Trop Med Hyg Date: 2021-06-28 Impact factor: 3.707
Authors: Luiz Roberto de Sousa Ulisses; Helen Souto Siqueira Cardoso; Inara Creão Costa Alves; Isabela Novais Medeiros; Camilla Garcia de Oliveira; Tiago Martins de Almeida; Fabíola Fernandes Dos Santos Castro; Claudia Neto Gonçalves Neves da Silva; Laura Viana de Lima; Renata Pereira Fontoura; Eduardo Resende Sousa E Silva; Pollyana Lopes de Araújo; Gustavo de Sousa Arantes Ferreira Journal: J Bras Nefrol Date: 2022 Jan-Mar